ArticleJournal of human hypertension2021
Reduced heart-rate variability and increased risk of hypertension-a prospective study of the ELSA-Brasil.
Article in Journal of human hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.Clinical physiology and functional imaging · 2025Trial
- Resistance exercise lowers blood pressure and improves vascular endothelial function in individuals with elevated blood pressure or stage-1 hypertension.American journal of physiology. Heart and circulatory physiology · 2024Trial
- Exercise Training Across the Hypertensive Heart Disease Continuum: Clinical Evidence and Implications for Prescription.Journal of cardiovascular development and disease · 2026Review
- Beat-to-Beat QT Variability: A Population Study of the QT Variability Index Composition.Diagnostics (Basel, Switzerland) · 2026Article
- Factors influencing heart rate variability in nurses following night shifts: a prospective observational clinical study.BMC nursing · 2025Article
- Article
- Longer respiratory events in childhood obstructive sleep apnea syndrome constitute a trait of older children with excessive daytime sleepiness.Scientific reports · 2025Article
- Association of Sports Practice in Childhood and Adolescence with Cardiac Autonomic Modulation in Adulthood: A Retrospective Epidemiological Study.Sports medicine - open · 2024Article
- Comparison of Heart Rate Variability in Thai Older Adults with Hypertension, Pre-Hypertension, and Normotension.TheScientificWorldJournal · 2024Article
- Article
- Association of Early Sports Practice with Cardiovascular Risk Factors in Community-Dwelling Adults: A Retrospective Epidemiological Study.Sports medicine - open · 2023Article
- The Role of Heart Rate Variability (HRV) in Different Hypertensive Syndromes.Diagnostics (Basel, Switzerland) · 2023Review
- Establishment of hypertension risk nomograms based on physical fitness parameters for men and women: a cross-sectional study.Frontiers in cardiovascular medicine · 2023Article
- Irregular sleep and cardiometabolic risk: Clinical evidence and mechanisms.Frontiers in cardiovascular medicine · 2023Review
- Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Differences in Nervous Autonomic Control in Response to a Single Session of Exercise in Bodybuilders Using Anabolic Androgenic Steroids.Journal of human kinetics · 2021Article
- SDNN24 Estimation from Semi-Continuous HR Measures.Sensors (Basel, Switzerland) · 2021Article
- A Comparative Cross-Sectional Study of Cardiac Autonomic Status by Five Minute Heart Rate Variability among Type 2 Diabetics, Hypertensives and Normotensive-Nondiabetics.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although autonomic disturbances are known to precede hypertension onset, the risks underlying different ranges of blood pressure and impaired cardiac autonomic modulation are still unknown. This study aimed to identify the risk of hypertension incidence related to low heart-rate variability profile in normotensive blood pressure subcategories: normal (<120/80 mmHg) and prehypertension (120/80-139/89 mmHg) in a 4-year follow-up. 7665 participants free of hypertension at baseline were examined. They were allocated into one of two groups (<P25 and ≥P25) based on age-specific value distributions of heart-rate variability ranges presented in the literature. The relationship between heart-rate variability parameters (SDNN, RMSSD, VLF, LF, and HF) and hypertension incidence was analyzed using Poisson regression. The reference for the independent variable in these regressions was the dataset with all HRV values ≥P25. After full adjustments for age, sex, ethnicity, educational level, body mass index, smoking status, glucose, insulin, dyslipidemia, alcohol consumption, and physical activity, low values for all heart-rate variability indices were significantly associated with an increased relative risk of developing hypertension in the overall sample. Individuals with normal BP levels presented an increased risk for low SDNN, VLF, and LF values, whereas the risk in prehypertensive participants was only verified for low VLF. In conclusion, cardio autonomic disturbances precede the incidence of clinical hypertension and are potentially involved in its pathophysiological basis and progression. Even individuals with normal blood pressure may be at an increased risk for future hypertension in the presence of reduced cardio autonomic control.
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Registered trials
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