ArticleMolecular psychiatry2021
Altered temporal, but intact spatial, features of transient network dynamics in psychosis.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Dynamic brain connectivity patterns induced by oxytocin: An fMRI Co-Activation pattern analysis study.Molecular psychiatry · 2026Article
- Flexible brain state engagement predicts cognitive control transdiagnostically.bioRxiv : the preprint server for biology · 2026Article
- Atypical Development of Functional Brain Networks in Neonates with Congenital Heart Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spatiotemporal complexity in the psychotic brain.Molecular psychiatry · 2026Article
- Reduced glymphatic clearance in early psychosis.Molecular psychiatry · 2025Article
- Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting-State fMRI Study Using Co-Activation Pattern Analysis.Human brain mapping · 2025Article
- Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder.JAMA network open · 2025Article
- Disorder-specific neurodynamic features in schizophrenia inferred by neurodynamic embedded contrastive variational autoencoder model.Translational psychiatry · 2024Article
- A longitudinal multimodal MRI study of the visual network in postoperative delirium.Brain imaging and behavior · 2024Article
- Article
- Methods for and Use of Functional Magnetic Resonance Imaging in Psychiatry.Advances in neurobiology · 2024Review
- Overcoming the translational crisis of contemporary psychiatry - converging phenomenological and spatiotemporal psychopathology.Molecular psychiatry · 2023Review
- Integrating subjective and objective-spatiotemporal approach to psychiatric disorders.Molecular psychiatry · 2023Article
- Altered Brain Dynamics Across Bipolar Disorder and Schizophrenia During Rest and Task Switching Revealed by Overlapping Brain States.Biological psychiatry · 2023Article
- Robust dynamic brain coactivation states estimated in individuals.Science advances · 2023Article
- Impaired dynamic functional brain properties and their relationship to symptoms in never treated first-episode patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Frequency-specific coactivation patterns in resting-state and their alterations in schizophrenia: An fMRI study.Human brain mapping · 2022Article
- Polygenic risk scores across the extended psychosis spectrum.Translational psychiatry · 2021Article
- Whole-Brain Functional Network Connectivity Abnormalities in Affective and Non-Affective Early Phase Psychosis.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Contemporary models of psychosis suggest that a continuum of severity of psychotic symptoms exists, with subthreshold psychotic experiences (PEs) potentially reflecting some genetic and environmental risk factors shared with clinical psychosis. Thus, identifying abnormalities in brain activity that manifest across this continuum can shed new light on the pathophysiology of psychosis. Here, we investigated the moment-to-moment engagement of brain networks ("states") in individuals with schizophrenia (SCZ) and PEs and identified features of these states that are associated with psychosis-spectrum symptoms. Transient brain states were defined by clustering "single snapshots" of blood oxygen level-dependent images, based on spatial similarity of the images. We found that individuals with SCZ (n = 35) demonstrated reduced recruitment of three brain states compared to demographically matched healthy controls (n = 35). Of these three illness-related states, one specific state, involving primarily the visual and salience networks, also occurred at a lower rate in individuals with persistent PEs (n = 22), compared to demographically matched healthy youth (n = 22). Moreover, the occurrence rate of this marker brain state was negatively correlated with the severity of PEs (r = -0.26, p = 0.003, n = 130). In contrast, the spatial map of this state appeared to be unaffected in the SCZ or PE groups. Thus, reduced engagement of a brain state involving the visual and salience networks was demonstrated across the psychosis continuum, suggesting that early disruptions of perceptual and affective function may underlie some of the core symptoms of the illness.
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