ArticleScientific reports2021
Radiolysis generates a complex organosynthetic chemical network.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A workflow for modeling radiolysis in chemically, physically, and geometrically complex scenarios.iScience · 2025Article
- Theoretical perspective on synthetic man-made life: Learning from the origin of life.Quantitative biology (Beijing, China) · 2023Review
- Tracing the Volatilomic Fingerprint of the Most Popular Italian Fortified Wines.Foods (Basel, Switzerland) · 2023Article
- Tracing the volatilomic fingerprint of grape pomace as a powerful approach for its valorization.Current research in food science · 2023Article
- Network Analysis Reveals Spatial Clustering and Annotation of Complex Chemical Spaces: Application to Astrochemistry.Analytical chemistry · 2022Article
- The hierarchical organization of autocatalytic reaction networks and its relevance to the origin of life.PLoS computational biology · 2022Article
- The Prebiotic Kitchen: A Guide to Composing Prebiotic Soup Recipes to Test Origins of Life Hypotheses.Life (Basel, Switzerland) · 2021Review
- Automated Exploration of Prebiotic Chemical Reaction Space: Progress and Perspectives.Life (Basel, Switzerland) · 2021Review
- The curious consistency of carbon biosignatures over billions of years of Earth-life coevolution.The ISME journal · 2021Review
- Prebiotic Reaction Networks in Water.Life (Basel, Switzerland) · 2020Review
- A continuous reaction network that produces RNA precursors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Hot Spring Hypothesis for an Origin of Life.Astrobiology · 2020Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The architectural features of cellular life and its ecologies at larger scales are built upon foundational networks of reactions between molecules that avoid a collapse to equilibrium. The search for life's origins is, in some respects, a search for biotic network attributes in abiotic chemical systems. Radiation chemistry has long been employed to model prebiotic reaction networks, and here we report network-level analyses carried out on a compiled database of radiolysis reactions, acquired by the scientific community over decades of research. The resulting network shows robust connections between abundant geochemical reservoirs and the production of carboxylic acids, amino acids, and ribonucleotide precursors-the chemistry of which is predominantly dependent on radicals. Moreover, the network exhibits the following measurable attributes associated with biological systems: (1) the species connectivity histogram exhibits a heterogeneous (heavy-tailed) distribution, (2) overlapping families of closed-loop cycles, and (3) a hierarchical arrangement of chemical species with a bottom-heavy energy-size spectrum. The latter attribute is implicated with stability and entropy production in complex systems, notably in ecology where it is known as a trophic pyramid. Radiolysis is implicated as a driver of abiotic chemical organization and could provide insights about the complex and perhaps radical-dependent mechanisms associated with life's origins.
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