Evidence map›Paper›PMID 33462305›Full record

ArticleScientific reports2021

Actinobacillus pleuropneumoniae exotoxin ApxI induces cell death via attenuation of FAK through LFA-1.

Siou-Cen Li, Yu-Tsen Cheng, Ching-Yang Wang, Jia-Ying Wu, Zeng-Weng Chen, Jyh-Perng Wang, Jiunn-Horng Lin, Shih-Ling Hsuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Phosphorylation of the βScientific reports · 2025
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  4. PKCActa pharmaceutica Sinica. B · 2024
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  5. Article
  6. Naringin's Alleviation of the Inflammatory Response Caused byInternational journal of molecular sciences · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Siou-Cen LiGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung City, 402, Taiwan.
Yu-Tsen ChengGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung City, 402, Taiwan.
Ching-Yang WangGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung City, 402, Taiwan.
Jia-Ying WuGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung City, 402, Taiwan.
Zeng-Weng ChenAnimal Technology Laboratories, Agricultural Technology Research Institute, Hsinchu City, 300, Taiwan.
Jyh-Perng WangAnimal Technology Laboratories, Agricultural Technology Research Institute, Hsinchu City, 300, Taiwan.
Jiunn-Horng LinAnimal Technology Laboratories, Agricultural Technology Research Institute, Hsinchu City, 300, Taiwan.
Shih-Ling HsuanGraduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung City, 402, Taiwan. hsuan@nchu.edu.tw.
National Chung Hsing University · TWAgricultural Technology Research Institute · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ApxI exotoxin is an important virulence factor derived from Actinobacillus pleuropneumoniae that causes pleuropneumonia in swine. Here, we investigate the role of lymphocyte function-associated antigen 1 (LFA-1, CD11a/CD18), a member of the β

Indexed as

Actinobacillus InfectionsActinobacillus pleuropneumoniaeAnimalsBacterial ProteinsCell DeathCells, CulturedFocal Adhesion Kinase 1Hemolysin ProteinsHumansLymphocyte Function-Associated Antigen-1Macrophages, AlveolarMiceProto-Oncogene Proteins c-aktSwineSwine DiseasesApxI toxin, BacteriaBacterial ProteinsFocal Adhesion Kinase 1Hemolysin ProteinsLymphocyte Function-Associated Antigen-1Proto-Oncogene Proteins c-akt

Identifiers

PMID33462305
PMCPMC7813829
OpenAlexW3124915882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.