ArticleScientific reports2021
Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Machine learning techniques for predicting neurodevelopmental impairments in premature infants: a systematic review.Frontiers in artificial intelligence · 2025Pooled it
- Pregnancy complications and autoimmune diseases in women: systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Targeted removal of soluble Fms-like tyrosine kinase 1 in very preterm preeclampsia: a pilot trial.Nature medicine · 2026Trial
- Prediction of motor developmental outcomes based on MRI radiomics in premature infants.Pediatric research · 2026Article
- Risk factors for neonatal brain injury in neonates born to mothers with preeclampsia: a retrospective study.BMC pregnancy and childbirth · 2026Article
- The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research.Journal of magnetic resonance imaging : JMRI · 2025Review
- Predicting complications in hypertensive disorders of pregnancy: external validation of a prognostic model for adverse perinatal outcomes.AJOG global reports · 2025Article
- Dietary supplements and prevention of preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Maternal Hypertension and Adverse Neurodevelopment in a Cohort of Preterm Infants.JAMA network open · 2025Article
- Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Approaching the paradoxical relationship between hypertensive disorders of pregnancy and cerebral palsy among infants born very preterm with very low birth weight.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning.Archives of gynecology and obstetrics · 2023Article
- Risk factors and machine learning prediction models for bronchopulmonary dysplasia severity in the Chinese population.World journal of pediatrics : WJP · 2023Article
- Gestational age-specific neonatal mortality in Hong Kong: a population-based retrospective study.World journal of pediatrics : WJP · 2023Article
- Impact of hypertensive disorders of pregnancy on neonatal outcomes among infants born at 24Frontiers in pediatrics · 2023Article
- Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood: national population based cohort study.BMJ (Clinical research ed.) · 2022Article
- Neonatal outcomes of twins <29 weeks gestation of mothers with hypertensive disorders of pregnancy.Pediatric research · 2022Article
- [Sex differences in clinical outcomes of extremely preterm infants/extremely low birth weight infants: a propensity score matching study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Mothers with hypertensive disorders of pregnancy increased risk of periventricular leukomalacia in extremely preterm or extremely low birth weight infants: A propensity score analysis.Frontiers in pediatrics · 2022Article
- Increased Risk for Respiratory Complications in Male Extremely Preterm Infants: A Propensity Score Matching Study.Frontiers in endocrinology · 2022Article
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12 authors at 2 institutions in 1 country.
Funding
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Abstract
To evaluate the impact of maternal hypertensive disorders of pregnancy (HDP) on mortality and neurological outcomes in extremely and very preterm infants using a nationwide neonatal database in Japan. This population-based retrospective study was based on an analysis of data collected by the Neonatal Research Network of Japan from 2003 to 2015 of neonates weighing 1,500 g or less at birth, between 22 and 31 weeks' gestation. A total of 21,659 infants were randomly divided into two groups, HDP (n = 4,584) and non-HDP (n = 4,584), at a ratio of 1:1 after stratification by four factors including maternal age, parity, weeks of gestation, and year of delivery. Short-term (neonatal period) and medium-term (3 years of age) mortality and neurological outcomes were compared between the two groups by logistic regression analyses. In univariate analysis, HDP was associated with an increased risk for in-hospital death (crude odds ratio [OR], 1.31; 95% confidence interval, 1.04-1.63) and a decreased risk for severe intraventricular haemorrhage (0.68; 0.53-0.87) and periventricular leukomalacia (0.60; 0.48-0.77). In multivariate analysis, HDP was significantly associated with a lower risk for in-hospital death (adjusted OR, 0.61; 0.47-0.80), severe intraventricular haemorrhage (0.47; 0.35-0.63), periventricular leukomalacia (0.59; 0.45-0.78), neonatal seizures (0.40; 0.28-0.57) and cerebral palsy (0.70; 0.52-0.95) at 3 years after adjustment for covariates including birth weight. These results were consistent with those of additional analyses, which excluded cases with histological chorioamnionitis and which divided the infants into two subgroups (22-27 gestational weeks and 28-31 gestational weeks). Maternal HDP was associated with an increased risk for in-hospital death without adjusting for covariates, but it was also associated with a lower risk for mortality and adverse neurological outcomes in extremely and very preterm infants if all covariates except HDP were identical.
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