ArticleScientific reports2021
Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- The Neural Correlates of Chewing Gum-A Neuroimaging Review of Its Effects on Brain Activity.Brain sciences · 2025Review
- The gamma rhythm as a guardian of brain health.eLife · 2024Review
- Correlation between spinal cord stimulation analgesia and cortical dynamics in pain management.Annals of clinical and translational neurology · 2024Article
- Peptidergic and functional delineation of the Edinger-Westphal nucleus.Cell reports · 2023Article
- Post-injury pain and behaviour: a control theory perspective.Nature reviews. Neuroscience · 2023Review
- Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice.The Journal of clinical investigation · 2023Article
- Sharp Tuning of Head Direction and Angular Head Velocity Cells in the Somatosensory Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The neurobiology of pain and facial movements in rodents: Clinical applications and current research.Frontiers in veterinary science · 2022Review
- From nociception to pain perception, possible implications of astrocytes.Frontiers in cellular neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is caused by tissue injury, inflammatory disease, pathogen invasion, or neuropathy. The perception of pain is attributed to the neuronal activity in the brain. However, the dynamics of neuronal activity underlying pain perception are not fully known. Herein, we examined theta-oscillation dynamics of local field potentials in the primary somatosensory cortex of a mouse model of formalin-induced pain, which usually shows a bimodal behavioral response interposed between pain-free periods. We found that formalin injection exerted a reversible shift in the theta-peak frequency toward a slower frequency. This shift was observed during nociceptive phases but not during the pain-free period and was inversely correlated with instantaneous pain intensity. Furthermore, instantaneous oscillatory analysis indicated that the probability of slow theta oscillations increased during nociceptive phases with an association of augmented slow theta power. Finally, cross-frequency coupling between theta and gamma oscillations indicated that the coupling peak frequency of theta oscillations was also shifted toward slower oscillations without affecting coupling strength or gamma power. Together, these results suggest that the dynamic changes in theta oscillations in the mouse primary somatosensory cortex represent the ongoing status of pain sensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.