ArticleScientific reports2021
Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Molecular basis of precision nutrition: Food components, microbiome-derived metabolites, and multi-omics modeling.Food chemistry. Molecular sciences · 2026Review
- Narrative review on bacteria-derived metabolites in the pathogenesis of ulcerative colitis.Clinical microbiology reviews · 2025Review
- Straining to define a healthy microbiome.mSphere · 2025Review
- The critical role of diet, exercise, and sleep in shaping the gut microbiota of children with idiopathic short stature: a Retrospective study.Frontiers in immunology · 2025Article
- Analysis of metagenomic data.Nature reviews. Methods primers · 2025Article
- Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans.Science (New York, N.Y.) · 2024Article
- A metagenomic approach to unveil the association between fecal gut microbiota and short-chain fatty acids in diarrhea caused by diarrheagenicMicrobial cell (Graz, Austria) · 2024Article
- Short-Chain Fatty Acids-A Product of the Microbiome and Its Participation in Two-Way Communication on the Microbiome-Host Mammal Line.Current obesity reports · 2023Review
- Ancient pathogens provide a window into health and well-being.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa.Nature communications · 2022Article
- Butyrate Production Pathway Abundances Are Similar in Human and Nonhuman Primate Gut Microbiomes.Molecular biology and evolution · 2022Article
- Gut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella-based trophic network.Nature microbiology · 2022Article
- Roles for non-human primate-associated phage diversity in improving medicine and public health.Evolution, medicine, and public health · 2022Article
- A Link between Chronic Kidney Disease and Gut Microbiota in Immunological and Nutritional Aspects.Nutrients · 2021Review
- Variation in Microbial Exposure at the Human-Animal Interface and the Implications for Microbiome-Mediated Health Outcome.mSystems · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
Abstract
High taxonomic diversity in non-industrial human gut microbiomes is often interpreted as beneficial; however, it is unclear if taxonomic diversity engenders ecological resilience (i.e. community stability and metabolic continuity). We estimate resilience through genus and species-level richness, phylogenetic diversity, and evenness in short-chain fatty acid (SCFA) production among a global gut metagenome panel of 12 populations (n = 451) representing industrial and non-industrial lifestyles, including novel metagenomic data from Burkina Faso (n = 90). We observe significantly higher genus-level resilience in non-industrial populations, while SCFA production in industrial populations is driven by a few phylogenetically closely related species (belonging to Bacteroides and Clostridium), meaning industrial microbiomes have low resilience potential. Additionally, database bias obfuscates resilience estimates, as we were 2-5 times more likely to identify SCFA-encoding species in industrial microbiomes compared to non-industrial. Overall, we find high phylogenetic diversity, richness, and evenness of bacteria encoding SCFAs in non-industrial gut microbiomes, signaling high potential for resilience in SCFA production, despite database biases that limit metagenomic analysis of non-industrial populations.
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