ArticleNature communications2021
Male fertility in Arabidopsis requires active DNA demethylation of genes that control pollen tube function.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- Occupancy-based mechanism is the chief mode of ROS1 function in preventing DNA hypermethylation.Nature plants · 2026Article
- Evolutionary history and genomic consequences of polyploidization in natural populations ofHorticulture research · 2026Article
- An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics.Nature communications · 2025Article
- An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics.bioRxiv : the preprint server for biology · 2025Article
- The 5-methylcytosine DNA glycosylase ROS1 prevents paternal genome hypermethylation in Arabidopsis endosperm.Genome biology · 2025Article
- Article
- Molecular mechanisms and biological functions of active DNA demethylation in plants.Epigenetics & chromatin · 2025Review
- Transgenerational Transmission of Epigenetic Marks During Reproduction inThe Yale journal of biology and medicine · 2025Review
- Pseudouridine guides germline small RNA transport and epigenetic inheritance.Nature structural & molecular biology · 2025Article
- Interactions between U and V sex chromosomes during the life cycle of Ectocarpus.Development (Cambridge, England) · 2024Article
- Potent pollen gene regulation by DNA glycosylases in maize.Nature communications · 2024Article
- SeqSNP-Based Targeted GBS Provides Insight into the Genetic Relationships among Global Collections ofGenes · 2024Article
- ARID1 is required to regulate and reinforce H3K9me2 in sperm cells in Arabidopsis.Nature communications · 2024Article
- Genome-Wide Analysis of DNA Demethylases in Land Plants and Their Expression Pattern in Rice.Plants (Basel, Switzerland) · 2024Article
- Molecular basis and evolutionary drivers of endosperm-based hybridization barriers.Plant physiology · 2024Review
- Functional identification of DNA demethylase geneFrontiers in plant science · 2024Article
- The ancestral chromatin landscape of land plants.The New phytologist · 2023Article
- Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity in plants.Genome biology · 2023Article
- Article
- Base Excision DNA Repair in Plants:International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Active DNA demethylation is required for sexual reproduction in plants but the molecular determinants underlying this epigenetic control are not known. Here, we show in Arabidopsis thaliana that the DNA glycosylases DEMETER (DME) and REPRESSOR OF SILENCING 1 (ROS1) act semi-redundantly in the vegetative cell of pollen to demethylate DNA and ensure proper pollen tube progression. Moreover, we identify six pollen-specific genes with increased DNA methylation as well as reduced expression in dme and dme;ros1. We further show that for four of these genes, reinstalling their expression individually in mutant pollen is sufficient to improve male fertility. Our findings demonstrate an essential role of active DNA demethylation in regulating genes involved in pollen function.
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Registered trials
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