ReviewPhysical biology2021
Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation.
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In one paragraph
Review in Physical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
–field-weighted citation impact
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Who cites it
46 citing papers in PubMed.
- To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility.Molecular microbiology · 2026Review
- Insight into the relationship between type IV pilus function and biofilm formation.Biochemical Society transactions · 2026Review
- A quantitative framework for multiscale analysis ofBiofilm · 2026Article
- Rage against the mean: a perspective on measuring fitness of individual phage particles.Npj viruses · 2026Review
- Role of Tad pili during the transition from planktonic to biofilm state inJournal of bacteriology · 2026Article
- Advances in phage therapy forFrontiers in microbiology · 2026Review
- Construction Biotechnology: Integrating Bacterial Systems into Civil Engineering Practices.Microorganisms · 2025Review
- Tat-dependent bundling pilus of a halophilic archaeon assembles by a strand donation mechanism and facilitates biofilm formation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- When the Last Line Fails: Characterization of Colistin-ResistantPathogens (Basel, Switzerland) · 2025Article
- Dissecting the physics of bacterial biofilms with agent-based simulations.Current opinion in solid state & materials science · 2025Article
- Review
- Evolutionary consequences of bacterial resistance to a flagellotropic phage.bioRxiv : the preprint server for biology · 2025Article
- Segmentation of dense and multi-species bacterial colonies using models trained on synthetic microscopy images.PLoS computational biology · 2025Article
- Physical communication pathways in bacteria: an extra layer to quorum sensing.Biophysical reviews · 2025Review
- Metareview: a survey of active matter reviews.The European physical journal. E, Soft matter · 2025Review
- A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer.Cell chemical biology · 2025Article
- Controlling noise with self-organized resetting.Communications physics · 2025Article
- Glycemic impact of cereal and legume-based bakery products: Implications for chronic disease management.Food chemistry: X · 2024Review
- Intrinsic antimicrobial resistance: Molecular biomaterials to combat microbial biofilms and bacterial persisters.Biomaterials · 2024Review
- Nanovibrational Stimulation ofACS nano · 2024Article
Corrections and comments
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Authors and funding
42 authors.
Gerard C L WongDepartment of Bioengineering, University of California-Los Angeles, Los Angeles, California, CA 90095, United States of America.ORCID 0000-0003-0893-6383
Jyot D AntaniArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, United States of America.ORCID 0000-0002-7402-983X
Pushkar P LeleArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, United States of America.
Jing ChenDepartment of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA24061, United States of America.
Beiyan NanDepartment of Biology, Texas A&M University, College Station, Texas, TX 77845, United States of America.ORCID 0000-0002-0326-9529
Marco J KühnInstitute of Bioengineering and Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Alexandre PersatInstitute of Bioengineering and Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Jean-Louis BruDepartment of Molecular Biology & Biochemistry, University of California-Irvine, California, CA 92697, United States of America.
Nina Molin Høyland-KroghsboDepartment of Plant and Environmental Sciences, University of Copenhagen, DK-1871 Frederiksberg, Denmark.ORCID 0000-0001-5904-8859
Albert SiryapornDepartment of Molecular Biology & Biochemistry, University of California-Irvine, California, CA 92697, United States of America.ORCID 0000-0002-2056-9937
Jacinta C ConradWilliam A Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, TX 77204, United States of America.ORCID 0000-0001-6084-4772
Francesco CarraraInstitute of Environmental Engineering, Department of Civil, Environmental and Geomatic Engineering, ETH Zurich, 8093 Zurich, Switzerland.
Yutaka YawataFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Roman StockerInstitute of Environmental Engineering, Department of Civil, Environmental and Geomatic Engineering, ETH Zurich, 8093 Zurich, Switzerland.
Yves V BrunUniversity of Montreal, Faculty of Medicine, Montreal, Quebec, H3C 3J7, Canada.
Gregory B WhitfieldUniversity of Montreal, Faculty of Medicine, Montreal, Quebec, H3C 3J7, Canada.
Calvin K LeeDepartment of Bioengineering, University of California-Los Angeles, Los Angeles, California, CA 90095, United States of America.ORCID 0000-0001-6789-0317
Jaime de AndaDepartment of Bioengineering, University of California-Los Angeles, Los Angeles, California, CA 90095, United States of America.
William C SchmidtDepartment of Bioengineering, University of California-Los Angeles, Los Angeles, California, CA 90095, United States of America.
Ramin GolestanianMax Planck Institute for Dynamics and Self-Organization (MPIDS), D-37077 Göttingen, Germany.ORCID 0000-0002-3149-4002
George A O'TooleDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, United States of America.
Kyle A FloydDepartment of Microbiology and Environmental Toxicology, University of California-Santa Cruz, Santa Cruz, California, CA 95060, United States of America.
Fitnat H YildizDepartment of Microbiology and Environmental Toxicology, University of California-Santa Cruz, Santa Cruz, California, CA 95060, United States of America.
Shuai YangCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China.
Fan JinCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China.
Masanori ToyofukuFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Leo EberlDepartment of Plant and Microbial Biology, University of Zürich, 8008 Zürich, Switzerland.
Nobuhiko NomuraFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Lori A ZacharoffDepartment of Physics and Astronomy, University of Southern California, Los Angeles, California, CA 90089, United States of America.
Mohamed Y El-NaggarDepartment of Physics and Astronomy, University of Southern California, Los Angeles, California, CA 90089, United States of America.
Sibel Ebru YalcinDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, CT 06516, United States of America.ORCID 0000-0002-6041-5297
Nikhil S MalvankarDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, CT 06516, United States of America.ORCID 0000-0001-5611-6633
Mauricio D Rojas-AndradeDepartment of Materials Science and Engineering, University of California-Irvine, Irvine, California CA 92697, United States of America.
Allon I HochbaumDepartment of Molecular Biology & Biochemistry, University of California-Irvine, California, CA 92697, United States of America.
Jing YanDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, CT 06511, United States of America.
Howard A StoneDepartment of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey, NJ 08544, United States of America.
Ned S WingreenDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, NJ 08544, United States of America.
Bonnie L BasslerDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, NJ 08544, United States of America.
Yilin WuDepartment of Physics and Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China.ORCID 0000-0002-0392-2137
Haoran XuDepartment of Physics and Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China.
Knut DrescherMax Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany.
Jörn DunkelDepartment of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, MA 02139-4307, United States of America.
Funding
Vibrio cholerae c-diGMP signaling: Motile to biofilm transition and transmissionR01AI102584 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2013 to 2023
$6.5MThermally robust chemotaxis and thermotaxis in Escherichia coliR01GM082938 · NIGMS · PRINCETON UNIVERSITY · PI WINGREEN, NED S · 2008 to 2025
$5.5MIntra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4MMathematical modeling of spatiotemporal and mechanical processes in cellular functionsR35GM138370 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Jing Chen · 2020 to 2026
$2.0MSurface sensing, memory, and motility control in biofilm formationR01AI143730 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI O'TOOLE, GEORGE A., WONG, GERARD C · 2019 to 2023
$2.0MMechanical Regulation of Ultra-Sensitivity in E. Coli Flagellar MotorsR01GM123085 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI LELE, PUSHKAR PRAKASH · 2017 to 2025
$1.8MThe Origin of Rod Shape in BacteriaR01GM129000 · NIGMS · TEXAS A&M UNIVERSITY · PI NAN, BEIYAN · 2018 to 2022
$1.6MBSLII Stationed Zeiss 880 Confocal Microscope with AiryscanS10OD023528 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2017 to 2017
$456kQuantitative Imaging and Analysis of Bacterial Biofilms from the Single Cell to the CollectiveR21AI146223 · NIAID · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L, STONE, HOWARD · 2019 to 2020
$446kReal-time metabolic analysis of virulence activation in P. aeruginosa using fluorescence lifetime imaging microscopy (FLIM)R21AI139968 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SIRYAPORN, ALBERT · 2019 to 2020
$382kHoward Hughes Medical InstituteNIAID NIH HHS R01 AI102584NIAID NIH HHS R01 AI143730NIAID NIH HHS R21 AI139968NIAID NIH HHS R21 AI146223NIGMS NIH HHS R01 GM082938NIGMS NIH HHS R01 GM123085NIGMS NIH HHS R01 GM129000NIGMS NIH HHS R35 GM138370NIGMS NIH HHS R37 GM065859NIH HHS S10 OD023528
Abstract
Bacterial biofilms are communities of bacteria that exist as aggregates that can adhere to surfaces or be free-standing. This complex, social mode of cellular organization is fundamental to the physiology of microbes and often exhibits surprising behavior. Bacterial biofilms are more than the sum of their parts: single-cell behavior has a complex relation to collective community behavior, in a manner perhaps cognate to the complex relation between atomic physics and condensed matter physics. Biofilm microbiology is a relatively young field by biology standards, but it has already attracted intense attention from physicists. Sometimes, this attention takes the form of seeing biofilms as inspiration for new physics. In this roadmap, we highlight the work of those who have taken the opposite strategy: we highlight the work of physicists and physical scientists who use physics to engage fundamental concepts in bacterial biofilm microbiology, including adhesion, sensing, motility, signaling, memory, energy flow, community formation and cooperativity. These contributions are juxtaposed with microbiologists who have made recent important discoveries on bacterial biofilms using state-of-the-art physical methods. The contributions to this roadmap exemplify how well physics and biology can be combined to achieve a new synthesis, rather than just a division of labor.
Indexed as
Bacterial Physiological PhenomenaBiofilmsBacterial AdhesionQuorum Sensingadhesionbiofilmscellular organisationmotilityphysiology of microbes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.