ArticleDisease models & mechanisms2021
Genetic background modifies vulnerability to glaucoma-related phenotypes in
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Article in Disease models & mechanisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Schlemm's Canal Development and Implications for Glaucoma Treatment.Annual review of vision science · 2026Review
- Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Intraocular pressure induced blood retinal barrier compromise in mouse models and human glaucoma.Nature communications · 2026Article
- Article
- Absence of Glaucoma in Tg-MYOCY437H Mice of Diverse Genetic Backgrounds.Investigative ophthalmology & visual science · 2025Article
- Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment.bioRxiv : the preprint server for biology · 2025Article
- TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma.Scientific reports · 2025Article
- Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma.eLife · 2025Article
- Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma.bioRxiv : the preprint server for biology · 2025Article
- FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-CADHERIN.Nature communications · 2025Article
- Structural framework to address variant-gene relationship in primary open-angle glaucoma.Vision research · 2025Review
- Article
- Transcriptomic profiling of Schlemm's canal cells reveals a lymphatic-biased identity and three major cell states.bioRxiv : the preprint server for biology · 2024Article
- TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage.Investigative ophthalmology & visual science · 2024Article
- Comparison of the Biomechanics of the Mouse Astrocytic Lamina Cribrosa Between Glaucoma and Optic Nerve Crush Models.Investigative ophthalmology & visual science · 2023Article
- Genetic background determines severity of Loxl1-mediated systemic and ocular elastosis in mice.Disease models & mechanisms · 2023Article
- Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.Investigative ophthalmology & visual science · 2022Review
- Quantification and image-derived phenotyping of retinal ganglion cell nuclei in the nee mouse model of congenital glaucoma.Experimental eye research · 2021Article
- Article
- Lack of Association Between Polymorphisms inFrontiers in genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Nicholas G TolmanHoward Hughes Medical Institute, Department of Ophthalmology, Columbia University Medical Center, and Zuckerman Mind Brain Behavior Institute, New York, NY 10027, USA.ORCID 0000-0002-3060-2999
Revathi BalasubramanianHoward Hughes Medical Institute, Department of Ophthalmology, Columbia University Medical Center, and Zuckerman Mind Brain Behavior Institute, New York, NY 10027, USA.ORCID 0000-0002-2209-0815
Danilo G MacalinaoThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0002-3188-2611
Alison L KearneyThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0002-3054-8769
Katharine H MacNicollThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0003-2766-0976
Christa L MontgomeryHoward Hughes Medical Institute, Department of Ophthalmology, Columbia University Medical Center, and Zuckerman Mind Brain Behavior Institute, New York, NY 10027, USA.
Wilhelmine N de VriesThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0001-8229-9357
Ian J JacksonMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0001-6526-0688
Sally H CrossMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0001-6518-6449
Krishnakumar KizhatilThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0003-3755-6101
K Saidas NairDepartments of Ophthalmology and Anatomy, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Simon W M JohnHoward Hughes Medical Institute, Department of Ophthalmology, Columbia University Medical Center, and Zuckerman Mind Brain Behavior Institute, New York, NY 10027, USA sj2967@cumc.columbia.edu.ORCID 0000-0002-4319-0356
Jackson Laboratory · USHoward Hughes Medical Institute · USInstitute of Genetics and Cancer · GBTufts University · USUniversity of California, San Francisco · US
Funding
Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9MFactors Determining Intraocular Pressure and Glaucoma SusceptibilityR01EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 2002 to 2018
$12.4MDoes VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?R01EY032062 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W, KIZHATIL, KRISHNAKUMAR · 2021 to 2025
$3.5MREPRODUCTIVE BIOLOGYT32HD007065 · NICHD · JACKSON LABORATORY · PI BRAUN, ROBERT E · 1985 to 2020
$2.6MDetermining How Lymphatic Molecules Control Conventional OutflowR01EY028175 · NEI · JACKSON LABORATORY · PI KIZHATIL, KRISHNAKUMAR · 2017 to 2021
$2.3MDetermining Molecular and Cellular Mechanisms of GlaucomaR01EY022891 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAIR, KAYARAT SAIDAS · 2013 to 2017
$2.0MThe Role of Refractive Error in the Etiology of GlaucomaR01EY027004 · NEI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHOQUET, HELENE · 2017 to 2020
$1.6MFACTORS DETERMINING INTRAOCULAR PRESSURER29EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 1997 to 2001
$227kMedical Research Council MC_PC_U127561112Medical Research Council MC_PC_U12756112Medical Research Council MC_UU_00007/4NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY011721NEI NIH HHS R01 EY022891NEI NIH HHS R01 EY027004NEI NIH HHS R01 EY028175NEI NIH HHS R01 EY032062NEI NIH HHS R29 EY011721NICHD NIH HHS T32 HD007065
Abstract
Variants in the LIM homeobox transcription factor 1-beta (
Indexed as
Genetic Predisposition to DiseaseAllelesAnimalsAnterior Eye SegmentCrosses, GeneticDisease Models, AnimalEye AbnormalitiesFemaleGenes, HomeoboxGenetic BackgroundGenotypeGlaucomaIntraocular PressureLIM-Homeodomain ProteinsMaleMiceLIM homeobox transcription factor 1 betaLIM-Homeodomain ProteinsTranscription FactorsGeneticsGlaucomaIntraocular pressureLmx1b
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.