Evidence map›Paper›PMID 33462117›Full record

ArticleDevelopment (Cambridge, England)2021

Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3.2 in the skeleton.

Joanna Smeeton, Natasha Natarajan, Arati Naveen Kumar, Tetsuto Miyashita, Pranidhi Baddam, Peter Fabian, Daniel Graf, J Gage Crump

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Zebrafish: an important model for understanding scoliosis.Cellular and molecular life sciences : CMLS · 2022
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Joanna SmeetonDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USAORCID 0000-0002-6126-2560
Natasha NatarajanDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Arati Naveen KumarDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Tetsuto MiyashitaDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, CanadaORCID 0000-0003-0050-4594
Pranidhi BaddamDepartment of Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, CanadaORCID 0000-0003-0232-2022
Peter FabianDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USAORCID 0000-0002-1096-6875
Daniel GrafDepartment of Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada
J Gage CrumpDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USAORCID 0000-0002-3209-0026
University of Southern California · USUniversity of Alberta · CA

Funding

Progenitor Regulation in Craniofacial Development and RegenerationR35DE027550 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRUMP, GAGE D · 2017 to 2024
$8.0M
Endogenous stem cells in jaw joint cartilage and ligament regenerationR00DE027218 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMEETON, JOANNA MARJORIE · 2020 to 2022
$729k
Single-cell analysis of the craniofacial skeletal stem cell nicheK99DE029858 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FABIAN, PETER · 2020 to 2021
$206k
NIDCR NIH HHS K99 DE029858NIDCR NIH HHS R00 DE027218NIDCR NIH HHS R35 DE027550
6 · The paper itself

Abstract

The regulated expansion of chondrocytes within growth plates and joints ensures proper skeletal development through adulthood. Mutations in the transcription factor

Indexed as

AnimalsBone and BonesCartilageChondrocytesDisease Models, AnimalEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHomeodomain ProteinsJawJointsMitosisMorpholinosMutationOsteochondrodysplasiasRNA-SeqSingle-Cell AnalysisHomeodomain ProteinsMorpholinosnkx3-2 protein, zebrafishTranscription FactorsZebrafish ProteinsChondrocyteJointNkx3.2ProliferationSpineZebrafish

Identifiers

PMID33462117
PMCPMC7860120
OpenAlexW3122898439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.