Evidence map›Paper›PMID 33462115›Full record

ArticleDevelopment (Cambridge, England)2021

Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.

Pauline Antonie Ulmke, Yuanbin Xie, Godwin Sokpor, Linh Pham, Orr Shomroni, Tea Berulava, Joachim Rosenbusch, Uttiya Basu, Andre Fischer, Huu Phuc Nguyen and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Built differently or defective: can RNA exosomopathies cause ribosome heterogeneity?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  4. Article
  5. Review
  6. Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Emerging Role of mFrontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Pauline Antonie UlmkeUniversity Medical Center, Georg-August- University Goettingen, Goettingen 37075, Germany.
Yuanbin XieUniversity Medical Center, Georg-August- University Goettingen, Goettingen 37075, Germany.ORCID 0000-0003-3621-9920
Godwin SokporUniversity Medical Center, Georg-August- University Goettingen, Goettingen 37075, Germany.
Linh PhamUniversity Medical Center, Georg-August- University Goettingen, Goettingen 37075, Germany.
Orr ShomroniMicroarray and Deep-Sequencing Core Facility, Georg-August- University Goettingen, Goettingen 37075, Germany.
Tea BerulavaGerman Center for Neurodegenerative Diseases, Goettingen 37075, Germany.
Joachim RosenbuschUniversity Medical Center, Georg-August- University Goettingen, Goettingen 37075, Germany.
Uttiya BasuDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Andre FischerGerman Center for Neurodegenerative Diseases, Goettingen 37075, Germany.
Huu Phuc NguyenDepartment of Human Genetics, Ruhr University of Bochum, Bochum 44801, Germany.
Jochen F StaigerUniversity Medical Center, Georg-August- University Goettingen, Goettingen 37075, Germany.
Tran TuocUniversity Medical Center, Georg-August- University Goettingen, Goettingen 37075, Germany tran.tuoc@ruhr-uni-bochum.de.ORCID 0000-0003-2079-7259
University of Göttingen · DEGerman Center for Neurodegenerative Diseases · DEColumbia University · USGannan Medical University · CNRuhr University Bochum · DE

Funding

Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic HypermutationR01AI099195 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2012 to 2026
$9.8M
Long noncoding RNA expressing genomic element that control antibody diversification and chromosomal integrity in B cellsR01AI134988 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2018 to 2026
$4.7M
The role of N6-methyladenosine RNA modification in programmed and aberrant DNA mutagenesis in B cellsR01AI143897 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2020 to 2026
$3.4M
NIAID NIH HHS R01 AI099195NIAID NIH HHS R01 AI134988NIAID NIH HHS R01 AI143897
6 · The paper itself

Abstract

Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels, including RNA decay. N

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsApoptosisApoptosis Regulatory ProteinsCell SurvivalComputational BiologyExoribonucleasesExosome Multienzyme Ribonuclease ComplexExosomesHumansMiceMice, Inbred C57BLMice, TransgenicProsencephalonRNARNA StabilityApoptosis Regulatory ProteinsExoribonucleasesExosome Multienzyme Ribonuclease ComplexPUMA protein, mouseRNATumor Suppressor Protein p53Tumor Suppressor ProteinsAen and Bbc3ApoptosisCortical developmentExosc10Exosome complexP53 pathwayRNA decay

Identifiers

PMID33462115
PMCPMC7888709
OpenAlexW3125784579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.