Evidence map›Paper›PMID 33462059›Full record

ArticleBMJ case reports2021

Severe acute mitral valve regurgitation in a COVID-19-infected patient.

Ayesha Khanduri, Usha Anand, Maged Doss, Louis Lovett

Open access · bronzeAbstract readCase ReportsVideo-Audio Media
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. COVID-19 as Potential Cause of Aortic Valvulitis.Methodist DeBakey cardiovascular journal · 2025
    Article
  3. COVID-19-associated MRSA infective endocarditis and mitral valve perforation: a case report.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Covid and Cardiovascular Diseases: Direct and Indirect Damages and Future Perspective.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ayesha KhanduriGraduate Medical Education, WellStar Health System, Marietta, Georgia, USA ayesha.khanduri@wellstar.org.
Usha AnandGraduate Medical Education, WellStar Health System, Marietta, Georgia, USA.
Maged DossGraduate Medical Education, WellStar Health System, Marietta, Georgia, USA.
Louis LovettGraduate Medical Education, WellStar Health System, Marietta, Georgia, USA.
WellStar Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing SARS-CoV-2 (COVID-19) pandemic has presented many difficult and unique challenges to the medical community. We describe a case of a middle-aged COVID-19-positive man who presented with pulmonary oedema and acute respiratory failure. He was initially diagnosed with acute respiratory distress syndrome. Later in the hospital course, his pulmonary oedema and respiratory failure worsened as result of severe acute mitral valve regurgitation secondary to direct valvular damage from COVID-19 infection. The patient underwent emergent surgical mitral valve replacement. Pathological evaluation of the damaged valve was confirmed to be secondary to COVID-19 infection. The histopathological findings were consistent with prior cardiopulmonary autopsy sections of patients with COVID-19 described in the literature as well as proposed theories regarding ACE2 receptor activity. This case highlights the potential of SARS-CoV-2 causing direct mitral valve damage resulting in severe mitral valve insufficiency with subsequent pulmonary oedema and respiratory failure.

Indexed as

Acute DiseaseAtrial FibrillationChordae TendineaeCOVID-19EchocardiographyElectrocardiographyHeart Valve Prosthesis ImplantationHumansMaleMiddle AgedMitral Valve InsufficiencyPulmonary EdemaRespiratory InsufficiencySARS-CoV-2Severity of Illness IndexShock, Cardiogeniccardiovascular medicineCardiovascular medicinegeneral practice / family medicineGeneral practice / family medicineinfectious diseasesInfectious diseasesmedical educationMedical educationvalvar diseasesValvar diseases

Identifiers

PMID33462059
PMCPMC7813411
OpenAlexW3125980942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.