Trial reportBMJ (Clinical research ed.)2021
Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial.
Trial report in BMJ (Clinical research ed.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02753751 (Optimizing Electronic Alerts for Acute Kidney Injury), which is not on this map. Cited by 100 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Electronic Alerts for Acute Kidney Injury
Who cites it
100 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- AI Models for Predicting Acute Kidney Injury (AKI) and Post-AKI Mortality: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- The influence of electronic AKI alert on prognosis of adult hospitalized patients: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Effect of electronic alerts on the care and outcomes in patients with acute kidney injury: a meta-analysis and trial sequential analysis.BMC medicine · 2024Pooled it
- Electronic Alert Systems for Patients With Acute Kidney Injury: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Effect of electronic records on mortality among patients in hospital and primary healthcare settings: a systematic review and meta-analyses.Frontiers in digital health · 2024Pooled it
- Predict, diagnose, and treat chronic kidney disease with machine learning: a systematic literature review.Journal of nephrology · 2023Pooled it
- Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Linear correlation between white blood cell counts and the progression and prognosis of acute kidney injury.The Journal of international medical research · 2025Trial
- Predictive Value of Anion Gap for Acute Kidney Injury Progression and Outcomes.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Non-linear association between AKI alert detection rate by physicians and medical costs.PloS one · 2025Trial
- Trial
- Automated Electronic Alert for the Care and Outcomes of Adults With Acute Kidney Injury: A Randomized Clinical Trial.JAMA network open · 2024Trial
- A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes.Nature communications · 2023Trial
- Electronic Health Record-Nested Reminders for Serum Lithium Level Monitoring in Patients With Mood Disorder: Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- The rate of acute kidney injury (AKI) alert detection by the attending physicians was associated with the prognosis of patients with AKI.Frontiers in public health · 2022Trial
- In-hospital electronic monitoring system approaches to epidemiologic investigation and predictive modeling of contrast-induced acute kidney injury.Renal failure · 2026Article
- Nephrology 2050: an evidence-informed roadmap from precision prevention to kidney regeneration.International urology and nephrology · 2026Review
- Association of ACEIs/ARBs treatment with clinical outcomes in acute kidney injury: a multicenter retrospective cohort analysis.BMC pharmacology & toxicology · 2026Article
- Development and evaluation of a clinical dashboard for nephrology inpatients: a pilot study.BMC medical informatics and decision making · 2026Article
- External Validation, Recalibration, and Extension of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children Using Multicenter Data.Critical care explorations · 2026Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
objectiveTo determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression of acute kidney injury.
designDouble blinded, multicenter, parallel, randomized controlled trial.
settingSix hospitals (four teaching and two non-teaching) in the Yale New Haven Health System in Connecticut and Rhode Island, US, ranging from small community hospitals to large tertiary care centers.
participants6030 adult inpatients with acute kidney injury, as defined by the Kidney Disease: Improving Global Outcomes (KDIGO) creatinine criteria.
interventionsAn electronic health record based "pop-up" alert for acute kidney injury with an associated acute kidney injury order set upon provider opening of the patient's medical record.
main outcome measuresA composite of progression of acute kidney injury, receipt of dialysis, or death within 14 days of randomization. Prespecified secondary outcomes included outcomes at each hospital and frequency of various care practices for acute kidney injury.
results6030 patients were randomized over 22 months. The primary outcome occurred in 653 (21.3%) of 3059 patients with an alert and in 622 (20.9%) of 2971 patients receiving usual care (relative risk 1.02, 95% confidence interval 0.93 to 1.13, P=0.67). Analysis by each hospital showed worse outcomes in the two non-teaching hospitals (n=765, 13%), where alerts were associated with a higher risk of the primary outcome (relative risk 1.49, 95% confidence interval 1.12 to 1.98, P=0.006). More deaths occurred at these centers (15.6% in the alert group
conclusionsAlerts did not reduce the risk of our primary outcome among patients in hospital with acute kidney injury. The heterogeneity of effect across clinical centers should lead to a re-evaluation of existing alerting systems for acute kidney injury.
trial registrationClinicalTrials.gov NCT02753751.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.