Evidence map›Paper›PMID 33461976›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2021

Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder.

Chencheng Zhang, Seung-Goo Kim, Jun Li, Yingying Zhang, Qiming Lv, Kristina Zeljic, Hengfen Gong, Hongjiang Wei, Wenjuan Liu, Bomin Sun and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Chencheng Zhang *Department of Neurosurgery, Center for Functional Neurosurgery, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.ORCID http://orcid.org/0000-0003-4472-4134
Seung-Goo Kim *Department of Psychiatry, Cambridge University, Cambridge, UK.
Jun LiDepartment of Neurosurgery, Center for Functional Neurosurgery, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.ORCID http://orcid.org/0000-0002-4589-7371
Yingying ZhangDepartment of Neurosurgery, Center for Functional Neurosurgery, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.
Qiming LvInstitute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai, China.
Kristina ZeljicInstitute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai, China.
Hengfen GongDepartment of Psychiatry, Pudong District Mental Health Center, Shanghai, China.
Hongjiang WeiInstitute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wenjuan LiuDepartment of Psychiatry, Zhongshan Hospital Fudan University, Shanghai, China.
Bomin SunDepartment of Neurosurgery, Center for Functional Neurosurgery, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.
Zheng WangUniversity of the Chinese Academy of Sciences, Beijing, China vv247@cam.ac.uk zheng.wang@ion.ac.cn.
Valerie VoonDepartment of Psychiatry, Cambridge University, Cambridge, UK vv247@cam.ac.uk zheng.wang@ion.ac.cn.
Shanghai Jiao Tong University · CNFudan University · CNChinese Academy of Sciences · CNDuke University · USShanghai Mental Health Center · CNSun Yat-sen University · CNUniversity of Cambridge · GB

Funding

Medical Research Council MR/P008747/1
6 · The paper itself

Abstract

objectivesSurgical procedures targeting the anterior limb of the internal capsule (aLIC) can be effective in patients with selected treatment-refractory obsessive-compulsive disorder (OCD). The aLIC consists of white-matter tracts connecting cortical and subcortical structures and show a topographical organisation. Here we assess how aLIC streamlines are affected in OCD compared with healthy controls (HCs) and which streamlines are related with post-capsulotomy improvement.

methodsDiffusion-weighted MRI was used to compare white-matter microstructure via the aLIC between patients with OCD (n=100, 40 women, mean of age 31.8 years) and HCs (n=88, 39 women, mean of age 29.6 years). For each individual, the fractional anisotropy (FA) and streamline counts were calculated for each white-matter fibre bundle connecting a functionally defined prefrontal and subcortical region. Correlations between tractography measures and pre-capsulotomy and post-capsulotomy clinical outcomes (in obsessive-compulsive, anxiety and depression scores 6 months after surgery) were assessed in 41 patients with OCD.

resultsHierarchical clustering dendrograms show an aLIC organisation clustering lateral and dissociating ventral and dorsal prefrontal-thalamic streamlines, findings highly relevant to surgical targeting. Compared with HCs, patients with OCD had lower aLIC FA across multiple prefrontal cortical-subcortical regions (p<0.0073, false discovery rate-adjusted). Greater streamline counts of the dorsolateral prefrontal-thalamic tracts in patients with OCD predicted greater post-capsulotomy obsessive-compulsive improvement (p=0.016). In contrast, greater counts of the dorsal cingulate-thalamic streamlines predicted surgical outcomes mediated by depressive and anxiety improvements.

conclusionsThese findings shed light on the critical role of the aLIC in OCD and may potentially contribute towards precision targeting to optimise outcomes in OCD.

Identifiers

PMID33461976
PMCPMC8142462
OpenAlexW3122321002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.