Evidence map›Paper›PMID 33461911›Full record

ArticleBrazilian journal of otorhinolaryngology

Management of laryngopharyngeal reflux in Brazil: a national survey.

Jerome R Lechien, Paulo S Perazzo, Fabio P Ceccon, Claudia A Eckley, Karen de Carvalho Lopes, Rebecca Maunsell, Melissa A G Avelino, Lee M Akst, Geraldo D Sant'Anna, Rui Imamura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Laryngopharyngeal Reflux Prevalence and Predictors Among Doctors.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  2. Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Jerome R LechienYoung-Otolaryngologists of the International Federations of Otorhinolaryngological Societies (YO-IFOS), Laryngopharyngeal Reflux Study Group, Paris, France; University of Mons (UMons), UMONS Research Institute for Health Sciences and Technology, Faculty of Medicine, Department of Human Anatomy and Experimental Oncology, Mons, Belgium; Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), School of Medicine, UFR Simone Veil, Foch Hospital, Department of Otorhinolaryngology and Head and Neck Surgery, Paris, France; Université Libre de Bruxelles, School of Medicine, CHU Saint-Pierre, CHU de Bruxelles, Department of Otorhinolaryngology and Head and Neck Surgery, Brussels, Belgium.
Paulo S PerazzoUniversidade Estadual da Bahia, Faculdade de Ciências Médicas, Escola de Medicina, Departamento de Otorrinolaringologia, Salvador, BA, Brazil.
Fabio P CecconUniversidade Federal de São Paulo (UNIFESP), Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.
Claudia A EckleyFleury Medicina e Saúde Laboratórios Diagnósticos, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.
Karen de Carvalho LopesUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Disciplina de Otologia e Otoneurologia, São Paulo, SP, Brazil.
Rebecca MaunsellUniversidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Campinas, SP, Brazil.
Melissa A G AvelinoUniversidade Federal de Goiás (UFG) Anápolis, Goiás, Brazil.
Lee M AkstJohns Hopkins Hospital, Department of Otolaryngology-Head Neck Surgery, Baltimore, United States.
Geraldo D Sant'AnnaUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Disciplina de Otorrinolaringologia, Porto Alegre, RS, Brazil.
Rui ImamuraUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Otorrinolaringologia, São Paulo, SP, Brazil. Electronic address: imamurar@terra.com.br.
Universidade Federal de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRJohns Hopkins Hospital · USSociedade Brasileira de Cirurgia de Cabeça e Pescoço · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal de Goiás · BRUniversity of Mons · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStudies assessing the management of laryngopharyngeal reflux by otolaryngologists have reported an important heterogeneity regarding the definition, diagnosis, and treatment, which leads to discrepancies in the management of the patient. Information about the current knowledge and practices of Brazilian otolaryngologists in laryngopharyngeal reflux is lacking.

objectiveTo investigate the trends in management of laryngopharyngeal reflux disease among Brazilian otolaryngologists.

methodsA survey was sent by email to the members of the Brazilian Association of Otolaryngology-Head Neck Surgery. This survey has initially been conducted by the laryngopharyngeal reflux study group of young otolaryngologists of the International Federation of Otolaryngological Societies.

resultsAccording to the survey responders, the prevalence of laryngopharyngeal reflux was estimated to be 26.8% of patients consulting in otolaryngology and the most common symptoms were globus sensation, throat clearing, cough and stomach acid reflux. Nasal obstruction, Eustachian tube dysfunction, acute and chronic otitis media, vocal fold nodules and hemorrhage were considered not associated with laryngopharyngeal reflux by the majority of responders. About 2/3 of Brazilian otolaryngologists based the diagnosis of laryngopharyngeal reflux on the assessment of both symptoms and findings and a positive response to empiric therapeutic trials. Proton pump inhibitor utilized once or twice daily, was the most commonly used therapeutic scheme. Only 21.4% of Brazilian otolaryngologists have heard about nonacid and mixed laryngopharyngeal reflux and the awareness about the usefulness of multichannel intraluminal impedance pH monitoring (MII-pH) was minimal; 30.5% of responders did not consider themselves as well-informed about laryngopharyngeal reflux.

conclusionAlthough the laryngopharyngeal reflux-related symptoms, main diagnostic and treatment approaches referred by Brazilian otolaryngologists are consistent with the literature, the survey identified some limitations, such as the insufficient awareness of the role of laryngopharyngeal reflux in many otolaryngological conditions and of the possibility of non-acid or mixed reflux in refractory cases. Future studies are needed to establish international recommendations for the management of laryngopharyngeal reflux disease.

Indexed as

Laryngopharyngeal RefluxOtolaryngologyBrazilHumansOtolaryngologistsProton Pump InhibitorsProton Pump InhibitorsAwarenessDisease managementGastroesophageal reflux, laryngitisGlobus sensation

Identifiers

PMID33461911
PMCPMC9615517
OpenAlexW3118200434

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.