Evidence map›Paper›PMID 33461849›Full record

ArticleBiosensors & bioelectronics2021

Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach.

Xiao Li, Zhen Qin, Hao Fu, Ted Li, Ran Peng, Zhijie Li, James M Rini, Xinyu Liu

Open access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.

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  8. Fluorescent immunoassay for chloramphenicol based on the label-free polyadenine-mediated spherical nucleic acids triggered signal amplification.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiao LiDepartment of Mechanical Engineering, McGill University, Montreal, QC, Canada; Department of Chemistry, Stanford University, Stanford, CA, USA.
Zhen QinDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
Hao FuDepartment of Mechanical Engineering, McGill University, Montreal, QC, Canada.
Ted LiDepartment of Mechanical Engineering, McGill University, Montreal, QC, Canada.
Ran PengDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
Zhijie LiDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada.
James M RiniDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada.
Xinyu LiuDepartment of Mechanical Engineering, McGill University, Montreal, QC, Canada; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada. Electronic address: xyliu@mie.utoronto.ca.
McGill University · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate, rapid, and low-cost molecular diagnostics is essential in managing outbreaks of infectious diseases, such as the pandemic of coronavirus disease 2019 (COVID-19). Accordingly, microfluidic paper-based analytical devices (μPADs) have emerged as promising diagnostic tools. Among the extensive efforts to improve the performance and usability of diagnostic tools, biosensing mechanisms based on electrochemical impedance spectroscopy (EIS) have shown great promise because of their label-free operation and high sensitivity. However, the method to improve EIS biosensing on μPADs is less explored. Here, we present an experimental approach to enhancing the performance of paper-based EIS biosensors featuring zinc oxide nanowires (ZnO NWs) directly grown on working electrodes (WEs). Through a comparison of different EIS settings and an examination of ZnO-NW effects on EIS measurements, we show that ZnO-NW-enhanced WEs function reliably with Faradaic processes utilizing iron-based electron mediators. We calibrate paper-based EIS biosensors with different morphologies of ZnO NWs and achieve a low limit of detection (0.4 pg ml

Indexed as

Biosensing TechniquesCOVID-19COVID-19 Serological TestingDielectric SpectroscopyEquipment DesignHumansLab-On-A-Chip DevicesLimit of DetectionNanowiresPaperSARS-CoV-2Zinc OxideZinc OxideCOVID-19Electrochemical impedance biosensingHIVMicrofluidic paper-based analytical devicesNanowiresPoint-of-care diagnosis

Identifiers

PMID33461849
PMCPMC7550100
OpenAlexW3092210401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.