Evidence map›Paper›PMID 33461759›Full record

ArticleSeminars in arthritis and rheumatism2021

Outcome domains reported by patients, caregivers, healthcare professionals and stakeholders for calcium pyrophosphate deposition (CPPD): A content analysis based on semi-structured qualitative interviews from the OMERACT CPPD working group.

Amy Fuller, Ken Cai, Cesar Diaz-Torne, Georgios Filippou, Tristan Pascart, Owen Hensey, David Grossberg, Robin Christensen, Beverley Shea, Jasvinder A Singh and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in arthritis and rheumatism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review: Outcome measures in calcium pyrophosphate deposition.Best practice & research. Clinical rheumatology · 2021
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 9 countries.

Amy FullerAcademic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK. Electronic address: amy.fuller@nottingham.ac.uk.
Ken CaiBone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Cesar Diaz-TorneDepartment of Rheumatology, Hospital de la Santa Creu i Sant Pau, Universitat Autonòma de Barcelona, Spain.
Georgios FilippouRheumatology Unit, ASST-Fatebenefratelli L, Sacco University Hospital, University of Milan, Italy.
Tristan PascartDepartment of Rheumatology, Hopital Saint-Philbert, Lille Catholic University, Lille, France.
Owen HenseyThe Central Remedial Clinic, Dublin, Ireland.
David GrossbergHoly Cross Hospital, Silver Spring, MD, USA; Suburban Hospital, Bethesda, MD, USA.
Robin ChristensenMusculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen & Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Denmark.
Beverley SheaOttawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Jasvinder A SinghMedicine Service, VA Medical Center, Birmingham, AL, USA; Department of Medicine at the School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA; Department of Epidemiology at the UAB School of Public Health, Birmingham, AL, USA.
Sara K TedeschiDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA.
Nicola DalbethBone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Abhishek AbhishekAcademic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
University of Auckland · NZUniversity of Nottingham · GBAlabama Department of Public Health · USASST Fatebenefratelli Sacco · ITBrigham and Women's Hospital · USCentral Remedial Clinic · IEHoly Cross Hospital · USHôpital Saint-Philibert · FRHospital de Sant Pau · ESUniversity of Ottawa · CAUniversity of Southern Denmark · DK

Funding

Studying pseudogout using naturallanguage processing and novelimaging approachesK23AR075070 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI TEDESCHI, SARA K. · 2019 to 2023
$937k
NIAMS NIH HHS K23 AR075070NIAMS NIH HHS L30 AR070514
6 · The paper itself

Abstract

introductionAlthough calcium pyrophosphate deposition (CPPD) disease is common, there are no validated outcome measures for clinical research in this condition. The aim of this study was to generate a list of outcome domains as reported by patients, their caregivers, healthcare professionals (HCPs) and stakeholders to inform the development of an Outcome Measures in Rheumatology (OMERACT) Core Domain Set for CPPD.

methodsPatients with CPPD and their caregivers, HCPs and stakeholders took part in semi-structured qualitative interviews to explore potential outcome domains for CPPD clinical research relevant to their lived experience and knowledge of CPPD. Interviews were conducted in six countries across three continents. Data was analysed using manifest content analysis to identify outcome domains, which were tabulated and mapped to the core areas as defined by the OMERACT Filter 2.1.

resultsThirty-six interviews were conducted in total. Participants comprised of 28 patients (six of which included a caregiver), seven HCPs and one stakeholder. The commonly identified (sub-) domains (d) across the 1) abnormalities/manifestations core area were joint pain (d = 35), joint swelling (d = 27), joint stiffness (d = 25), CPPD flares (d = 25); 2) life-impact core area were overall function (d=35), and specifically the ability to complete daily tasks (d = 25); and 3) societal/resource use core area were use of analgesic medicines (d = 26). Patients more commonly reported joint swelling, stiffness and range of movement, and use of analgesics while HCPs more commonly reported domains relating to presence of CPP crystals, radiologic calcification, joint damage, time to diagnosis and suitability of treatment.

conclusionAmong a number of potential outcome domains identified, articular manifestations, function and analgesic use were most frequently mentioned by participants. These findings will be used to develop an OMERACT Core Domain Set for CPPD.

Indexed as

ChondrocalcinosisRheumatologyCalcium PyrophosphateCaregiversDelivery of Health CareHumansCalcium PyrophosphateContent analysisCPPDOutcome domains

Identifiers

PMID33461759
PMCPMC8205943
OpenAlexW3120746408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.