Evidence map›Paper›PMID 33461755›Full record

ArticleFertility and sterility2021

Machine-learning algorithm incorporating capacitated sperm intracellular pH predicts conventional in vitro fertilization success in normospermic patients.

Stephanie Jean Gunderson, Lis Carmen Puga Molina, Nicholas Spies, Paula Ania Balestrini, Mariano Gabriel Buffone, Emily Susan Jungheim, Joan Riley, Celia Maria Santi

Abstract read
In one paragraph

Article in Fertility and sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. NaInternational journal of molecular sciences · 2023
    Review
  10. SLO3: A Conserved Regulator of Sperm Membrane Potential.International journal of molecular sciences · 2023
    Review
  11. Observational
  12. Review
  13. Live-Birth Prediction of Natural-CycleFrontiers in endocrinology · 2022
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Stephanie Jean GundersonDepartment of OB/GYN, Washington University School of Medicine, Saint Louis, Missouri.
Lis Carmen Puga MolinaDepartment of OB/GYN, Washington University School of Medicine, Saint Louis, Missouri.
Nicholas SpiesDepartment of OB/GYN, Washington University School of Medicine, Saint Louis, Missouri.
Paula Ania BalestriniInstituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina.
Mariano Gabriel BuffoneInstituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina.
Emily Susan JungheimDepartment of Obstetrics/Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Joan RileyDepartment of OB/GYN, Washington University School of Medicine, Saint Louis, Missouri.
Celia Maria SantiDepartment of OB/GYN, Washington University School of Medicine, Saint Louis, Missouri. Electronic address: santic@wustl.edu.

Funding

SLO3 KO MOUSE: A TOOL TO REVEAL VOLTAGE-DEPENDENT PROCESSES IN SPERM FERTILITYR01HD069631 · NICHD · WASHINGTON UNIVERSITY · PI SANTI, CELIA M · 2011 to 2022
$3.3M
SLO3 K Channel: A Novel Target for ContraceptionR01HD095628 · NICHD · WASHINGTON UNIVERSITY · PI SANTI, CELIA M · 2017 to 2017
$278k
NICHD NIH HHS R01 HD069631NICHD NIH HHS R01 HD095628
6 · The paper itself

Abstract

objectiveTo measure human sperm intracellular pH (pH

designSpermatozoa from 76 IVF patients were capacitated in vitro. Flow cytometry was used to measure sperm pH

settingAcademic medical center. PATIENT(S): Normospermic men undergoing IVF. Patients were excluded if they used frozen sperm, had known male factor infertility, or used intracytoplasmic sperm injection only. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Successful conventional IVF. RESULT(S): Sperm pH CONCLUSION(S): Sperm pH

Indexed as

AlgorithmsMachine LearningAdultFemaleFertilization in VitroFlow CytometryForecastingHumansHydrogen-Ion ConcentrationInfertility, MaleIntracellular FluidMaleSemen AnalysisSperm Capacitationcapacitationconventional IVFHuman spermintracellular pHmachine learning

Identifiers

PMID33461755
PMCPMC9110269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.