SynthesisSystematic reviews2021
Diagnosis and treatment of Rosai-Dorfman disease of the spine: a systematic literature review.
Synthesis in Systematic reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Gastrocsoleus lengthening in combination with tibialis anterior tendon shortening for equinus deformity in children with cerebral palsy: a systematic review.Systematic reviews · 2025Pooled it
- Posterior mediastinal soft-tissue Rosai-Dorfman disease mimicking a neurogenic tumor.Radiology case reports · 2026Article
- SWI combined with cMRI and CT in the differentiating of intracranial Rosai-Dorfman disease from fibrous meningioma.BMC medical imaging · 2026Article
- Isolated spinal Rosai-Dorfman disease with secondary hypertrophic pachymeningitis: A case report with 20-year follow-up, highlighting rapid recurrence andSurgical neurology international · 2026Article
- Nasal Rosai-Dorfman disease: A case report and review of the literature.SAGE open medical case reports · 2026Article
- Spine-limited Rosai-Dorfman disease in a patient with ankylosing spondylitis - A rare mimicker of spinal tumors.Surgical neurology international · 2026Article
- Long-term management of orbital Rosai-Dorfman disease with re-irradiation for locoregional recurrence: a case report.Frontiers in oncology · 2026Article
- Efficacy of Radiotherapy in Patients with Relapsing Primary Rosai-Dorfman Disease of the Nasal Cavity.Medicina (Kaunas, Lithuania) · 2025Article
- A rare presentation of Rosai-Dorfman disease as a single dural-based lumbar intradural lesion: A case report.Heliyon · 2024Article
- Rosai-Dorfman Disease, Presenting as a Right Atrial Mass with Involvement of the Tricuspid Valve in a 54-Year-Old Woman.The American journal of case reports · 2024Article
- Rosai-Dorfman disease of the cauda equina: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Spinal Rosai-Dorfman disease-a report of 2 cases and review of literature.Spinal cord series and cases · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review and summarize the clinical features, diagnosis, treatment strategies, and prognosis of spinal Rosai-Dorfman disease (RDD).
methodsRDD is also termed as sinus histiocytosis with massive lymphadenopathy. We searched the databases of PubMed, Elsevier ScienceDirect, SpringerLink, and OVID. The keywords were Rosai-Dorfman disease and spine/central nervous system. Research articles and case reports with accessibility to full texts regarding spinal RDD were eligible for the inclusion. A total of 62 articles were included, and they contained 69 cases. We extracted the information of interest and analyzed them using SPSS statistics package.
resultsThe average age was 33.1 ± 18.3 years. The ratio of males to females was 1.9/1. Overall, 63 cases presented with spine-related symptoms. A total of 27 cases (39.1%) had multi-organ lesions, and 12 cases had records of massive lymphadenopathy. Among 47 cases who first manifested spine-related symptoms, 93.6% were preoperatively misdiagnosed. The disease had a predilection for cervical spine (38.8%) and thoracic spine (40.3%). 62.9% of lesions were dura-based. Surgery remained the mainstream treatment option (78.8%), with or without adjuvant therapies. Total lesion resection was achieved in 34.8% of cases. The rate of lesion recurrence/progression was 19.5%, which was marginally lower for total resection than for non-total resection.
conclusionSpinal RDD has no pathognomonic clinical and imaging features. Most cases first present with spine-relevant symptoms. Massive lymphadenopathy is not common, but a tendency for multi-organ involvement should be considered. Spinal RDD has a high recurrence rate; thus, total resection is the treatment of choice. Adjuvant therapies are indicated for multi-organ lesions and residual lesions. A wait and watch strategy is recommended for asymptomatic patients. Herein, a workflow of diagnosis and treatment of the spinal RDD is established.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.