Evidence map›Paper›PMID 33461591›Full record

ArticleArthritis research & therapy2021

Is gene expression among women with rheumatoid arthritis dysregulated during a postpartum flare?

Matthew Wright, Mette K Smed, J Lee Nelson, Jørn Olsen, Merete L Hetland, Vibeke Zoffmann, Damini Jawaheer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Matthew WrightChildren's Hospital Oakland Research Institute, UCSF Benioff Children's Hospital Oakland, 5700 Martin Luther King Jr. Way, Oakland, CA, 94609, USA.
Mette K SmedJuliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
J Lee NelsonFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jørn OlsenUniversity of California Los Angeles, Los Angeles, CA, USA.
Merete L HetlandDANBIO Registry and Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases VRR, Rigshospitalet, Glostrup, Denmark.
Vibeke ZoffmannJuliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Damini JawaheerChildren's Hospital Oakland Research Institute, UCSF Benioff Children's Hospital Oakland, 5700 Martin Luther King Jr. Way, Oakland, CA, 94609, USA. Damini.Jawaheer@ucsf.edu.ORCID 0000-0003-4954-874X
University of Copenhagen · DKCopenhagen University Hospital · DKUCSF Benioff Children's Hospital · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Washington · US

Funding

The Pregnancy Transcriptome in Rheumatoid Arthritis - RenewalR01AR073111 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Damini Jawaheer · 2017 to 2026
$4.6M
Gene Expression Profiling in a Prospective Rheumatoid Arthritis Pregnancy CohortR21AR057931 · NIAMS · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI JAWAHEER, DAMINI · 2010 to 2011
$334k
NIAMS NIH HHS R01 AR073111NIAMS NIH HHS R21 AR057931NIAMS NIH HHS R21AR057931
6 · The paper itself

Abstract

backgroundTo evaluate our hypotheses that, when rheumatoid arthritis (RA) flares postpartum, gene expression patterns are altered compared to (a) healthy women, (b) RA women whose disease activity is low or in remission postpartum, and (c) pre-pregnancy expression profiles.

methodsTwelve women with RA and five healthy women were included in this pilot study. RA disease activity and postpartum flare were assessed using the Clinical Disease Activity Index (CDAI). Total RNA from frozen whole blood was used for RNA sequencing. Differential gene expression within the same women (within-group) over time, i.e., postpartum vs. third trimester (T3) or pre-pregnancy (T0), were examined, using a significance threshold of q < 0.05 and fold-change ≥ 2.

resultsNine of the women with RA experienced a flare postpartum (RA

conclusionsThe large majority of gene expression changes between T3 and 3 months postpartum among RA women who flared postpartum reflected normal postpartum changes also seen among healthy women. Nonetheless, during a postpartum flare, a set of immune-related genes showed dysregulated expression compared to healthy women and women with RA whose disease activity was low or in remission during the same time frame, while other genes demonstrated significant differences in expression compared to RA pre-pregnancy levels.

Indexed as

Arthritis, RheumatoidFemaleGene ExpressionHumansPilot ProjectsPostpartum PeriodPregnancySequence Analysis, RNADisease activityGene expressionPostpartum flareRheumatoid arthritisRNA-seq

Identifiers

PMID33461591
PMCPMC7812735
OpenAlexW3121430985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.