Evidence map›Paper›PMID 33461577›Full record

ArticleJournal of nanobiotechnology2021

STED lithography in microfluidics for 3D thrombocyte aggregation testing.

Bianca Buchegger, Alexander Tanzer, Sandra Posch, Christian Gabriel, Thomas A Klar, Jaroslaw Jacak

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bianca BucheggerInstitute of Applied Physics and Linz Institute of Technology (LIT), Johannes Kepler University Linz, Altenberger Straße 69, 4040, Linz, Austria.
Alexander TanzerInstitute of Applied Physics and Linz Institute of Technology (LIT), Johannes Kepler University Linz, Altenberger Straße 69, 4040, Linz, Austria.
Sandra PoschInstitute of Biophysics, Johannes Kepler University Linz, Gruberstraße 40, 4020, Linz, Austria.
Christian GabrielLudwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, 1200, Vienna, Austria.
Thomas A KlarInstitute of Applied Physics and Linz Institute of Technology (LIT), Johannes Kepler University Linz, Altenberger Straße 69, 4040, Linz, Austria.
Jaroslaw JacakUniversity of Applied Sciences, Upper Austria School of Medical Engineering and Applied Social Sciences, Garnisonstraße 21, 4020, Linz, Austria. jaroslaw.jacak@fh-linz.at.ORCID http://orcid.org/0000-0002-4989-1276
Johannes Kepler University of Linz · ATLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA · ATUpper Austrian Research · AT

Funding

Austrian Science Fund P26461Austrian Science Fund FWF P 26461
6 · The paper itself

Abstract

Three-dimensional photopolymerization techniques such as multiphoton polymerization lithography (MPL) and stimulated emission depletion (STED) lithography are powerful tools for fabricating structures in the sub-µm range. Combining these techniques with microfluidics enables us to broaden the range of their applications. In this study, we show a microfluidic device enhanced with MPL structures carrying STED-lithographically written nanoanchors that promote binding of the von Willebrand factor (vWF). The density of vWF is adjusted by varying the number of the nanoanchors on the 3D structures. This allows us to study the impact of the density of vWF on the activation of thrombocytes. The activation of the thrombocytes seems to decrease with the density of vWF on the 3D scaffolds inside the microfluidic channels.

Indexed as

Blood PlateletsHumansImmunoglobulin GLab-On-A-Chip DevicesMicrofluidicsPolymerizationProtein Bindingvon Willebrand FactorImmunoglobulin Gvon Willebrand FactorMicrofluidicsMultiphoton polymerization lithographyStimulated emission depletion lithographyThrombocyte activationVon Willebrand factor

Identifiers

PMID33461577
PMCPMC7814651
OpenAlexW3123028065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.