Evidence map›Paper›PMID 33461340›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2021

The effect of ultrasound cavitation on endothelial cells.

Madhumithra Subramanian Karthikesh, Xinmai Yang

Open access · bronzeAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
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  16. Analyzing Gene Expression After Administration of Low-Intensity Therapeutic Ultrasound in Human Islet Cells.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Madhumithra Subramanian KarthikeshBioengineering Program and Institute for Bioengineering Research, University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0001-6397-9357
Xinmai YangBioengineering Program and Institute for Bioengineering Research, University of Kansas, Lawrence, KS 66045, USA.
University of Kansas · US

Funding

Precisely removing microvessels by photo-mediated ultrasound therapyR01EY029489 · NEI · UNIVERSITY OF KANSAS LAWRENCE · PI YANG, XINMAI · 2018 to 2021
$1.8M
Photo-mediated ultrasound therapy for treatment of cutaneous vascular malformationsR41EB030875 · NIBIB · PHOTOSONOX LLC · PI WANG, XUEDING, YANG, XINMAI · 2020 to 2020
$325k
NEI NIH HHS R01 EY029489NIBIB NIH HHS R41 EB030875
6 · The paper itself

Abstract

Acoustic cavitation has been widely explored for both diagnostic and therapeutic purposes. Ultrasound-induced cavitation, including inertial cavitation and non-inertial cavitation, can cause microstreaming, microjet, and free radical formation. The acoustic cavitation effects on endothelial cells have been studied for drug delivery, gene therapy, and cancer therapy. Studies have demonstrated that the ultrasound-induced cavitation effect can treat cancer, ischaemia, diabetes, and cardiovascular diseases. In this minireview, we will review the impact of ultrasound-induced cavitation on the endothelial cells such as cell permeability, cell proliferation, gene expression regulation, cell viability, hemostasis interaction, oxygenation, and variation in the level of calcium ions, ceramide, nitric oxide (NO) and nitric oxide synthase (NOS) activity. The applications of these effects and the cavitation mechanism involved will be summarized, demonstrating the important role of acoustic cavitation in non-invasive ultrasound treatment of various physiological conditions.

Indexed as

Drug Delivery SystemsMicrobubblesAcousticsEndothelial CellsHumansPermeabilityUltrasonographycellular effectsfree radical formationinertial cavitationmicrostreamingUltrasound cavitation

Identifiers

PMID33461340
PMCPMC8719027
OpenAlexW3125169772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.