Evidence map›Paper›PMID 33461165›Full record

ArticleAging2021

Platelet-derived biomaterials-mediated improvement of bone injury through migratory ability of embryonic fibroblasts:

Yen-Ru Chou, Wen-Cheng Lo, Navneet Kumar Dubey, Jui-Hua Lu, Hen-Yu Liu, Ching-Yu Tsai, Yue-Hua Deng, Chi-Ming Wu, Mao-Suan Huang, Win-Ping Deng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yen-Ru ChouGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Wen-Cheng LoSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Navneet Kumar DubeySchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Jui-Hua LuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Hen-Yu LiuStem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Ching-Yu TsaiSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Yue-Hua DengSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Chi-Ming WuStem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Mao-Suan HuangDepartment of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan.
Win-Ping DengSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Taipei Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWTunghai University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bony injuries lead to compromised skeletal functional ability which further increase in aging population due to decreased bone mineral density. Therefore, we aimed to investigate the therapeutic potential of platelet-derived biomaterials (PDB) against bone injury. Specifically, we assessed the impact of PDB on osteo-inductive characteristics and migration of mouse embryonic fibroblasts (MEFs). Osteogenic lineage, matrix mineralization and cell migration were determined by gene markers (RUNX2, OPN and OCN), alizarin Red S staining, and migration markers (FAK, pFAK and Src) and EMT markers, respectively. The therapeutic impact of TGF-β1, a key component of PDB, was confirmed by employing inhibitor of TGF-β receptor I (Ti). Molecular imaging-based

Indexed as

Biocompatible MaterialsBone RegenerationCell MovementOsteogenesisAnimalsBlood PlateletsBone DensityCalcification, PhysiologicCell LineageChemokine CXCL12Core Binding Factor Alpha 1 SubunitEpithelial-Mesenchymal TransitionFemurFibroblastsFocal Adhesion Kinase 1In Vitro TechniquesBiocompatible MaterialsChemokine CXCL12Core Binding Factor Alpha 1 SubunitCxcl12 protein, mouseCXCR4 protein, mouseFocal Adhesion Kinase 1OsteocalcinOsteopontinPtk2 protein, mouseReceptors, CXCR4Runx2 protein, mouseSpp1 protein, mousesrc-Family KinasesTgfb1 protein, mouseTransforming Growth Factor beta1bone injuryfibroblasts migrationosteogenesisplatelet-derived biomaterialsTGF-β1

Identifiers

PMID33461165
PMCPMC7906152
OpenAlexW3121780404

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.