Evidence map›Paper›PMID 33461144›Full record

ArticleBioorganic & medicinal chemistry2021

Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors.

Francesca Curreli, Shahad Ahmed, Sofia M Benedict Victor, Ildar R Iusupov, Evgeny A Spiridonov, Dmitry S Belov, Andrea Altieri, Alexander V Kurkin, Asim K Debnath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Antiviral Protein-Protein Interaction Inhibitors.Journal of medicinal chemistry · 2024
    Review
  4. Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca CurreliLaboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10065, USA.
Shahad AhmedLaboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10065, USA.
Sofia M Benedict VictorLaboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10065, USA.
Ildar R IusupovEDASA Scientific, Scientific Park, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Evgeny A SpiridonovEDASA Scientific, Scientific Park, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Dmitry S BelovEDASA Scientific, Scientific Park, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Andrea AltieriEDASA Scientific, Scientific Park, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Alexander V KurkinEDASA Scientific, Scientific Park, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Asim K DebnathLaboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10065, USA. Electronic address: adebnath@nybc.org.

Funding

Design of inhibitors targeted to the CD4 binding site on HIV-1 gp120R01AI104416 · NIAID · NEW YORK BLOOD CENTER · PI DEBNATH, ASIM K · 2013 to 2022
$7.9M
NIAID NIH HHS R01 AI104416
6 · The paper itself

Abstract

We presented our continuing stride to optimize the second-generation NBD entry antagonist targeted to the Phe43 cavity of HIV-1 gp120. We have synthesized thirty-eight new and novel analogs of NBD-14136, earlier designed based on a CH

Indexed as

Anti-HIV AgentsCD4 AntigensDose-Response Relationship, DrugDrug DesignHIV-1HIV Envelope Protein gp120HIV Fusion InhibitorsMicrobial Sensitivity TestsMolecular StructureSmall Molecule LibrariesStructure-Activity RelationshipAnti-HIV AgentsCD4 AntigensHIV Envelope Protein gp120HIV Fusion InhibitorsSmall Molecule LibrariesBroad-spectrumCytotoxicityENV-pseudovirusGp120 entry-antagonistHIV-1selectivity index (SI)Structure–activity relationship (SAR)

Identifiers

PMID33461144
PMCPMC7856678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.