Evidence map›Paper›PMID 33461032›Full record

SynthesisSeizure2021

Can antiepileptic efficacy and epilepsy variables be studied from electronic health records? A review of current approaches.

Barbara M Decker, Chloé E Hill, Steven N Baldassano, Pouya Khankhanian

Abstract readSystematic Review
In one paragraph

Synthesis in Seizure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Barbara M DeckerCenter for Neuroengineering and Therapeutics, Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, United States. Electronic address: Barbara.decker@pennmedicine.upenn.edu.
Chloé E HillDepartment of Neurology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, United States.
Steven N BaldassanoCenter for Neuroengineering and Therapeutics, Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, United States.
Pouya KhankhanianCenter for Neuroengineering and Therapeutics, Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, United States.

Funding

Institutional Career Development CoreKL2TR002241 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELLINGROD, VICKI L · 2017 to 2021
$6.9M
Neurologic Clinical Epidemiology Training ProgramT32NS061779 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider, Allison Willis · 2008 to 2026
$4.6M
Postdoctoral Training Program in Genomic MedicineT32HG009495 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Katherine L. Nathanson, Bogdan Pasaniuc · 2017 to 2026
$4.2M
Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Remapping neurology through translation and innovationT32NS091008 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AGUIRRE, GEOFFREY KARL, JENSEN, FRANCES E · 2015 to 2024
$3.0M
NCATS NIH HHS KL2 TR002241NHGRI NIH HHS T32 HG009495NINDS NIH HHS T32 NS061779NINDS NIH HHS T32 NS091006NINDS NIH HHS T32 NS091008
6 · The paper itself

Abstract

As automated data extraction and natural language processing (NLP) are rapidly evolving, improving healthcare delivery by harnessing large data is garnering great interest. Assessing antiepileptic drug (AED) efficacy and other epilepsy variables pertinent to healthcare delivery remain a critical barrier to improving patient care. In this systematic review, we examined automatic electronic health record (EHR) extraction methodologies pertinent to epilepsy. We also reviewed more generalizable NLP pipelines to extract other critical patient variables. Our review found varying reports of performance measures. Whereas automated data extraction pipelines are a crucial advancement, this review calls attention to standardizing NLP methodology and accuracy reporting for greater generalizability. Moreover, the use of crowdsourcing competitions to spur innovative NLP pipelines would further advance this field.

Indexed as

EpilepsyNeurodegenerative DiseasesAnticonvulsantsElectronic Health RecordsHumansNatural Language ProcessingAnticonvulsantsAntiepileptic drug efficacyAutomated extractionElectronic health recordEpilepsyNatural language processing

Identifiers

PMID33461032
PMCPMC7897304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.