ArticleBrain stimulation
Bidirectional and state-dependent modulation of brain activity by transcranial focused ultrasound in non-human primates.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 72 citations in OpenAlex.
- Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus.Nature communications · 2026Article
- Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation.Nature communications · 2026Article
- Differential effects of focused ultrasound neuromodulation in Parkinson's disease mice versus healthy mice.Journal of neural engineering · 2026Article
- Magnetic Resonance Imaging Monitoring of the Safety of Repeated Low-Intensity Focused Ultrasound Exposure at Three Brain Locations.Neuromodulation : journal of the International Neuromodulation Society · 2026Article
- From Ablation to Neuromodulation Platform: The Evolving Role of Magnetic Resonance-Guided Focused Ultrasound in Functional Neurosurgery.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Mapping and modulating brain dynamics in aging and neurodegeneration with electroencephalography and integrated neurotechnologies in primates.Frontiers in neuroscience · 2026Review
- Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging.Science advances · 2025Article
- State-dependent neurovascular modulation induced by transcranial ultrasound stimulation.Medical & biological engineering & computing · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Modulating nociception networks: the impact of low-intensity focused ultrasound on thalamocortical connectivity.Brain communications · 2025Article
- Transcranial focused ultrasound remotely modulates extrastriate visual cortex by stimulating frontal eye field with subregion specificity.Journal of neural engineering · 2024Article
- Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.Neuron · 2024Article
- Ultrasound pulse repetition frequency preferentially activates different neuron populations independent of cell type.Journal of neural engineering · 2024Article
- Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling.iScience · 2024Article
- Brain activity changes after high/low frequency stimulation in a nonhuman primate model of central post-stroke pain.Scientific reports · 2024Article
- Article
- Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention.Nature communications · 2024Article
- Towards an ion-channel-centric approach to ultrasound neuromodulation.Current opinion in behavioral sciences · 2024Article
- Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study.bioRxiv : the preprint server for biology · 2024Article
- Opportunities and obstacles in non-invasive brain stimulation.Frontiers in human neuroscience · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Transcranial focused ultrasound (FUS) stimulation under MRI guidance, coupled with functional MRI (fMRI) monitoring of effects, offers a precise, noninvasive technology to dissect functional brain circuits and to modulate altered brain functional networks in neurological and psychiatric disorders. Here we show that ultrasound at moderate intensities modulated neural activity bi-directionally. Concurrent sonication of somatosensory areas 3a/3b with 250 kHz FUS suppressed the fMRI signals produced there by peripheral tactile stimulation, while at the same time eliciting fMRI activation at inter-connected, off-target brain regions. Direct FUS stimulation of the cortex resulted in different degrees of BOLD signal changes across all five off-target regions, indicating that its modulatory effects on active and resting neurons differed. This is the first demonstration of the dual suppressive and excitative modulations of FUS on a specific functional circuit and of ability of concurrent FUS and MRI to evaluate causal interactions between functional circuits with neuron-class selectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.