Evidence map›Paper›PMID 33460651›Full record

ArticleThe Journal of biological chemistry

Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry.

Katarzyna Szymczak-Kulus, Sascha Weidler, Anna Bereznicka, Krzysztof Mikolajczyk, Radoslaw Kaczmarek, Bartosz Bednarz, Tao Zhang, Anna Urbaniak, Mariusz Olczak, Enoch Y Park and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Chemical and Enzymatic Synthesis of Sialylated Glycoforms of Human Erythropoietin.Angewandte Chemie (International ed. in English) · 2021
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Katarzyna Szymczak-KulusLaboratory of Glycobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Sascha WeidlerDepartment of Bioorganic Chemistry, University of Bayreuth, Bayreuth, Germany.
Anna BereznickaLaboratory of Glycobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Krzysztof MikolajczykLaboratory of Glycobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Radoslaw KaczmarekLaboratory of Glycobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Bartosz BednarzLaboratory of Molecular Biology of Microorganisms, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Tao ZhangCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Anna UrbaniakDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Mariusz OlczakDepartment of Biochemistry, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Enoch Y ParkLaboratory of Biotechnology, Shizuoka University, Shizuoka, Japan.
Edyta MajorczykFaculty of Physical Education and Physiotherapy, Opole University of Technology, Opole, Poland.
Katarzyna KapczynskaLaboratory of Medical Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Jolanta LukasiewiczLaboratory of Microbial Immunochemistry and Vaccines, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Carlo UnverzagtDepartment of Bioorganic Chemistry, University of Bayreuth, Bayreuth, Germany.
Marcin CzerwinskiLaboratory of Glycobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland. Electronic address: marcin.czerwinski@hirszfeld.pl.
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLLeiden University Medical Center · NLUniversity of Bayreuth · DEOpole University of Technology · PLShizuoka University · JPUniversity of Wrocław · PLWrocław University of Environmental and Life Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human Gb3/CD77 synthase, encoded by the A4GALT gene, is an unusually promiscuous glycosyltransferase. It synthesizes the Galα1→4Gal linkage on two different glycosphingolipids (GSLs), producing globotriaosylceramide (Gb3, CD77, P

Indexed as

AcetylgalactosamineAcetylglucosamineAnimalsBinding SitesCarbohydrate SequenceCHO CellsCricetulusEnterohemorrhagic Escherichia coliGalactoseGalactosyltransferasesGene ExpressionGlobosidesGlucoseHumansModels, MolecularMutationAcetylgalactosamineAcetylglucosaminegalactopyranosyl-1-4-N-acetylgalactosaminyl-1-3-galactopyranosyl-1-4-galactopyranosyl-1-4-glucopyranosylceramidegalactopyranosyl-1-4-paraglobosideGalactoseGalactosyltransferasesGlobosidesglobotriaosylceramideGlucoseNOR2 glycolipidRecombinant ProteinsShiga Toxin 1Shiga Toxin 2TrihexosylceramidesUDP-galactose-lactosylceramide alpha 1-4-galactosyltransferaseA4GALTglobotriaosylceramide (Gb3)glycolipidglycoproteinglycosylation inhibitorglycosyltransferaseN-glycanP1 antigenreceptorShiga toxin

Identifiers

PMID33460651
PMCPMC7949097
OpenAlexW3119251452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.