Evidence map›Paper›PMID 33460646›Full record

ArticleThe Journal of biological chemistry

Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria.

Jean-Marc DeKeyser, Christopher H Thompson, Alfred L George

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  6. Functional Characterization of a De NovoNeurology. Genetics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jean-Marc DeKeyserDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Christopher H ThompsonDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Alfred L GeorgeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: al.george@northwestern.edu.
Northwestern University · US

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KISKINIS, EVANGELOS · 2018 to 2022
$12.1M
NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

Mutations in genes encoding the human-brain-expressed voltage-gated sodium (Na

Indexed as

Promoter Regions, GeneticBase SequenceCloning, MolecularDNA, ComplementaryEscherichia coliGene ExpressionHEK293 CellsHumansMembrane PotentialsMutagenesis, Site-DirectedNAV1.1 Voltage-Gated Sodium ChannelNAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesPlasmidsProtein EngineeringDNA, ComplementaryNAV1.1 Voltage-Gated Sodium ChannelNAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelRecombinant ProteinsSCN1A protein, humanSCN8A protein, humanautismbrainelectrophysiologyepilepsymolecular biologyneurological diseaseplasmidsodium channel

Identifiers

PMID33460646
PMCPMC7948969
OpenAlexW3125504374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.