Evidence map›Paper›PMID 33460641›Full record

ArticleDevelopmental biology2021

Early patterning of ABCB, ABCC, and ABCG transporters establishes unique territories of small molecule transport in embryonic mesoderm and endoderm.

Catherine S Schrankel, Amro Hamdoun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  3. Semi-automated, high-content imaging of drug transporter knockout sea urchin (Lytechinus pictus) embryos.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Catherine S SchrankelCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego. 9500 Gilman Drive, La Jolla, CA, 92093-0202, USA.
Amro HamdounCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego. 9500 Gilman Drive, La Jolla, CA, 92093-0202, USA. Electronic address: ahamdoun@ucsd.edu.
Scripps Institution of Oceanography · US

Funding

Identity, mechanisms and early life impacts of transporter interfering compoundsR01ES027921 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, GEOFFREY A, HAMDOUN, AMRO M · 2018 to 2022
$3.0M
Molecular Mechanisms of Marine Organohalogen Bioaccumulation and NeurotoxicityR01ES030318 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMDOUN, AMRO M, PESSAH, ISAAC N · 2018 to 2022
$826k
Identifying the ABCs of xenobiotic metabolism in protecting the germ line lineageF32ES029843 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHRANKEL, CATHERINE SARAH · 2018 to 2022
$238k
NIEHS NIH HHS F32 ES029843NIEHS NIH HHS R01 ES027921NIEHS NIH HHS R01 ES030318
6 · The paper itself

Abstract

Directed intercellular movement of diverse small molecules, including metabolites, signal molecules and xenobiotics, is a key feature of multicellularity. Networks of small molecule transporters (SMTs), including several ATP Binding Cassette (ABC) transporters, are central to this process. While small molecule transporters are well described in differentiated organs, little is known about their patterns of expression in early embryogenesis. Here we report the pattern of ABC-type SMT expression and activity during the early development of sea urchins. Of the six major ABCs in this embryo (ABCB1, -B4, -C1, -C4, -C5 and -G2), three expression patterns were observed: 1) ABCB1 and ABCC1 are first expressed ubiquitously, and then become enriched in endoderm and ectoderm-derived structures. 2) ABCC4 and ABCC5 are restricted to a ring of mesoderm in the blastula and ABCC4 is later expressed in the coelomic pouches, the embryonic niche of the primordial germ cells. 3) ABCB4 and ABCG2 are expressed exclusively in endoderm-fated cells. Assays with fluorescent substrates and inhibitors of transporters revealed a ring of ABCC4 efflux activity emanating from ABCC4

Indexed as

AnimalsATP-Binding Cassette TransportersBiological TransportEndodermFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalIn Situ HybridizationIntestinal MucosaIntestinesMesodermSea UrchinsSignal TransductionATP-Binding Cassette TransportersABC transportersGut developmentMesoderm signalingMRPSea urchinSmall molecule

Identifiers

PMID33460641
PMCPMC8171262
OpenAlexW3120685980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.