Evidence map›Paper›PMID 33460572›Full record

ArticleThe Lancet. Respiratory medicine2021

Assessing the importance of interleukin-6 in COVID-19 - Authors' reply.

Daniel E Leisman, Lukas Ronner, Rachel Pinotti, Matthew D Taylor, Pratik Sinha, Carolyn S Calfee, Alexandre V Hirayama, Fiore Mastroianni, Cameron J Turtle, Michael O Harhay and 2 more

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Daniel E LeismanDepartment of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Feinstein Institute for Medical Research, Manhasset, NY, USA. Electronic address: dleisman@mgh.harvard.edu.
Lukas RonnerDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Rachel PinottiLevy Library, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthew D TaylorFeinstein Institute for Medical Research, Manhasset, NY, USA; Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, NY, USA; Zucker School of Medicine at Hofstra-Northwell, New York, NY, USA.
Pratik SinhaDepartment of Anesthesiology, Division of Critical Care, Washington University School of Medicine in St Louis, St Louis, MO, USA.
Carolyn S CalfeeDepartment of Anesthesia and Perioperative Care, University of California, San Francisco School of Medicine, San Francisco, CA, USA; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
Alexandre V HirayamaClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Fiore MastroianniDivision of Pulmonary and Critical Care Medicine, Northwell Health, New York, NY, USA.
Cameron J TurtleIntegrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Pulmonary and Critical Care Medicine, Northwell Health, New York, NY, USA.
Michael O HarhayDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Palliative and Advanced Illness Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Matthieu LegrandDepartment of Anesthesia and Perioperative Care, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
Clifford S DeutschmanFeinstein Institute for Medical Research, Manhasset, NY, USA; Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, NY, USA; Zucker School of Medicine at Hofstra-Northwell, New York, NY, USA.

Funding

Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
Orexinergic Modulation of Experimental SepsisR01GM121102 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DEUTSCHMAN, CLIFFORD SCOTT, PAVLOV, VALENTIN ATANASSOV · 2017 to 2020
$1.6M
Effects of Memory T Cells on the Response to Cecal Ligation and PunctureK08GM132794 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TAYLOR, MATTHEW DAVID · 2019 to 2022
$782k
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureR00HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL141678NHLBI NIH HHS R35 HL140026NIGMS NIH HHS K08 GM132794NIGMS NIH HHS R01 GM121102
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19CytokinesHumansInterleukin-6SARS-CoV-2SyndromeCytokinesInterleukin-6

Identifiers

PMID33460572
PMCPMC7834405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.