Evidence map›Paper›PMID 33460319›Full record

Trial reportBrain and behavior2020

Off-line effects of alpha-frequency transcranial alternating current stimulation on a visuomotor learning task.

Taiki Harada, Masayuki Hara, Kojiro Matsushita, Kenji Kawakami, Keisuke Kawakami, Masaya Anan, Hisato Sugata

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. [Microstate dynamics in motor imagery of stroke patients with transcranial alternating current stimulation modulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  5. Neural Mechanisms Underlying Robust Target Selection in Response to Microstimulation of the Oculomotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Taiki HaradaDepartment of Rehabilitation, Oita University Hospital, Oita, Japan.
Masayuki HaraGraduate School of Science and Engineering, Saitama University, Saitama, Japan.
Kojiro MatsushitaDepartment of Mechanical Engineering, Gifu University, Gifu, Japan.
Kenji KawakamiFaculty of Welfare and Health Science, Oita University, Oita, Japan.
Keisuke KawakamiFaculty of Welfare and Health Science, Oita University, Oita, Japan.
Masaya AnanFaculty of Welfare and Health Science, Oita University, Oita, Japan.
Hisato SugataFaculty of Welfare and Health Science, Oita University, Oita, Japan.ORCID 0000-0001-7362-295X
Oita University · JPGifu University · JPOita University Hospital · JPSaitama University · JP

Funding

Japan Society for the Promotion of Science 16K16429Japan Society for the Promotion of Science 18H03132Japan Society for the Promotion of Science LondonTATEISI science and technology foundation 2171012
6 · The paper itself

Abstract

introductionIt has been suggested that transcranial alternating current stimulation (tACS) at both alpha and beta frequencies promotes motor function as well as motor learning. However, limited information exists on the aftereffects of tACS on motor learning and neurophysiological profiles such as entrainment and neural plasticity in parallel. Therefore, in the present study, we examined the effect of tACS on motor learning and neurophysiological profiles using an off-line tACS condition.

methodsThirty-three healthy participants were randomly assigned to 10 Hz, 20 Hz, or the sham group. Participants performed visuomotor learning tasks consisting of a baseline task (preadaptation task) and training task (adaptation task) to reach a target with a lever-type controller. Electroencephalography was recorded from eight locations during the learning tasks. tACS was performed between the preadaptation task and adaptation task over the left primary motor cortex for 10 min at 1 mA.

resultsAs a result, 10 Hz tACS was shown to be effective for initial angular error correction in the visuomotor learning tasks. However, there were no significant differences in neural oscillatory activities among the three groups.

conclusionThese results suggest that initial motor learning can be facilitated even when 10 Hz tACS is applied under off-line conditions. However, neurophysiological aftereffects were recently demonstrated to be induced by tACS at individual alpha frequencies rather than fixed alpha tACS, which suggests that the neurophysiological aftereffects by fixed frequency stimulation in the present study may have been insufficient to generate changes in oscillatory neural activity.

Indexed as

Motor CortexTranscranial Direct Current StimulationElectroencephalographyHumansLearningNeuronal PlasticityaftereffectalphaEEGoff‐line conditiontACSvisuomotor learning task

Identifiers

PMID33460319
PMCPMC7507357
OpenAlexW3045511837

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.