Evidence map›Paper›PMID 33460210›Full record

ArticleJournal of medical primatology2020

Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission.

Kimberly Schmitt, James Curlin, Leila Remling-Mulder, Ryan Moriarty, Kelly Goff, Shelby O'Connor, Mark Stenglein, Preston Marx, Ramesh Akkina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kimberly SchmittDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-8445-3570
James CurlinDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-9944-7173
Leila Remling-MulderDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Ryan MoriartyUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Kelly GoffTulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Shelby O'ConnorUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mark StengleinDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Preston MarxTulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Ramesh AkkinaDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Modeling the molecular evolution of SIV to HIV using humanized miceR01AI123234 · NIAID · COLORADO STATE UNIVERSITY · PI AKKINA, RAMESH · 2016 to 2020
$2.4M
National Institute of Allergy and Infectious Diseases RO1 AI123234NCATS NIH HHS UL1 TR002535NIAID NIH HHS R01 AI123234NIH HHS OD011104NIH HHS P51 OD011106NIH HHS P51OD011106
6 · The paper itself

Abstract

HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4

Indexed as

MutationPan troglodytesAnimalsApe DiseasesDisease Models, AnimalEvolution, MolecularHIV-1Simian Immunodeficiency VirusCross‐species SIV transmissionHIV‐1 viral evolution from SIVhu‐HSC mice for cross‐species viral transmissionSIV chimpanzee evolution toward HIV‐1SIVcpz infection in humanized mice

Identifiers

PMID33460210
PMCPMC8177655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.