Evidence map›Paper›PMID 33460025›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Measurement of Lung Vessel and Epithelial Permeability In Vivo with Evans Blue.

Prestina Smith, Lauren A Jeffers, Michael Koval

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
54.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Dual pKa Lipid Nanoparticles for Lung-tropic mRNA Delivery and pH-Programmed Endosomal Escape.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  9. The ARDS microenvironment enhances MSC-induced repair via VEGF in experimental acute lung inflammation.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
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  12. International journal of molecular sciences · 2023
    Article
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  18. Biomedical optics express · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Prestina SmithDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Lauren A JeffersDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Michael KovalDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. mhkoval@emory.edu.
Emory University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Purinergic Regulation of Veinous Endothelial PermeabilityR01HL137112 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson, MICHAEL H. KOVAL · 2018 to 2026
$4.7M
Alcohol and the alveolar epithelial barrierR01AA025854 · NIAAA · EMORY UNIVERSITY · PI KOVAL, MICHAEL H. · 2017 to 2021
$1.9M
Causes of Lung Barrier Dysfunction in a Translational Model of Chronic Alcohol IngestionF31HL149323 · NHLBI · EMORY UNIVERSITY · PI JEFFERS, LAUREN ANN · 2019 to 2021
$139k
NHLBI NIH HHS F31 HL149323NHLBI NIH HHS R01 HL137112NIAAA NIH HHS R01 AA025854NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

Lung fluid balance is maintained in part by the barriers formed by the pulmonary microvasculature and alveolar epithelium. Failure of either of these barriers leads to pulmonary edema, which limits lung function and exacerbates the severity of acute lung injury. Here we describe a method using Evans Blue dye to simultaneously measure the function of vascular and epithelial barriers of murine lungs in vivo.

Indexed as

LungAcute Lung InjuryAnimalsCapillary PermeabilityEvans BlueMicePermeabilityPulmonary AlveoliPulmonary EdemaEvans BlueAcute respiratory distress syndromeAlveolar epitheliumLung barrier functionPulmonary edemaTight junctionsVascular endothelium

Identifiers

PMID33460025
PMCPMC8249315
OpenAlexW3122802654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.