Evidence map›Paper›PMID 33460012›Full record

ArticleJournal of endocrinological investigation2021

Trends in thyroid function testing, neck ultrasound, thyroid fine needle aspiration, and thyroidectomies in North-eastern Italy.

L Dal Maso, C Panato, A De Paoli, V Mattioli, D Serraino, R Elisei, G Zoppini, C Gobitti, E Borsatti, E Di Felice and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 3 countries.

L Dal MasoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via Franco Gallini 2, 33081, Aviano, PN, Italy. epidemiology@cro.it.ORCID http://orcid.org/0000-0001-6163-200X
C PanatoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via Franco Gallini 2, 33081, Aviano, PN, Italy.
A De PaoliEpidemiological Department, Azienda Zero, Via J. Avanzo, 35, 35132, Padua, Italy.
V MattioliCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via Franco Gallini 2, 33081, Aviano, PN, Italy.
D SerrainoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via Franco Gallini 2, 33081, Aviano, PN, Italy.
R EliseiUnit of Endocrinology, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy.
G ZoppiniEndocrinology, Diabetes and Metabolism, Department of Medicine, University and Hospital Trust of Verona, Verona, Italy.
C GobittiRadiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081, Aviano, Italy.
E BorsattiNuclear Medicine Unit, CRO Aviano National Cancer Institute, Via Franco Gallini, 2, 33081, Aviano, Italy.
E Di FeliceAuthority for Healthcare and Welfare, Emilia Romagna Regional Health Service, Bologna, Italy.
F FalciniRomagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola, Italy.
S FerrettiFerrara Cancer Registry, University of Ferrara, Azienda USL Ferrara, Ferrara, Italy.
S FrancisciNational Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
P Giorgi RossiReggio Emilia Cancer Registry, Epidemiology Unit, AUSL ASMN-IRCCS, Azienda USL di Reggio Emilia, Reggio Emilia, Italy.
S GuzzinatiEpidemiological Department, Azienda Zero, Via J. Avanzo, 35, 35132, Padua, Italy.
G MazzoleniSouth Tyrol Cancer Registry, Bolzano, Italy.
D PierannunzioNational Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
S PifferTrento Province Cancer Registry, Unit of Clinical Epidemiology, Trento, Italy.
S VaccarellaSection of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
M VicentiniReggio Emilia Cancer Registry, Epidemiology Unit, AUSL ASMN-IRCCS, Azienda USL di Reggio Emilia, Reggio Emilia, Italy.
M ZorziEpidemiological Department, Azienda Zero, Via J. Avanzo, 35, 35132, Padua, Italy.
S FranceschiCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via Franco Gallini 2, 33081, Aviano, PN, Italy.
U FedeliEpidemiological Department, Azienda Zero, Via J. Avanzo, 35, 35132, Padua, Italy. ugo.fedeli@azero.veneto.it.ORCID http://orcid.org/0000-0002-9939-3398
DEPTH Working Group
Centro di Riferimento Oncologico · ITRegione del Veneto · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITIstituto Superiore di Sanità · ITAzienda Ospedaliera Universitaria Pisana · ITCentre international de recherche sur le cancer · FRIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITNational Cancer Institute · UAUniversity of Ferrara · ITUniversity of Verona · IT

Funding

World Health Organization 001
6 · The paper itself

Abstract

purposeEvidence of an increased diagnostic pressure on thyroid has emerged over the past decades. This study aimed to provide estimates of a wide spectrum of surveillance indicators for thyroid dysfunctions and diseases in Italy.

methodsA population-based study was conducted in North-eastern Italy, including 11.7 million residents (20% of the total Italian population). Prescriptions for TSH testing, neck ultrasound or thyroid fine needle aspiration (FNA), surgical procedures, and drugs for hypo- or hyperthyroidism were extracted from regional health databases. Proportions and rates of selected examinations were calculated from 2010 to 2017, overall and by sex, calendar years, age, and region.

resultsBetween 2010 and 2017 in North-eastern Italy, 24.5% of women and 9.8% of men received at least one TSH test yearly. In 2017, 7.1% of women and 1.5% of men were prescribed drugs for thyroid dysfunction, 94.6% of whom for hypothyroidism. Neck ultrasound examinations were performed yearly in 6.9% of women and 4.6% of men, with a nearly two-fold variation between areas. Thyroid FNA and thyroidectomies were three-fold more frequent in women (394 and 85 per 100,000) than in men (128 and 29 per 100,000) with a marked variation between areas. Both procedures decreased consistently after 2013.

conclusionsThe results of this population-based study describe recent variations over time and between surrounding areas of indicators of 'diagnostic pressure' on thyroid in North-eastern Italy. These results emphasize the need to harmonize practices and to reduce some procedures (e.g., neck ultrasound and total thyroidectomies) in certain areas.

Indexed as

Biopsy, Fine-NeedleThyroid DiseasesThyroidectomyThyroid Function TestsThyroid GlandUltrasonographyAdultAgedFemaleHumansItalyMaleMedical OverusePatient Acceptance of Health CarePopulation SurveillanceSex FactorsFine needle aspirationItalyNeck ultrasoundThyroidectomiesThyroid stimulation hormones (TSH)

Identifiers

PMID33460012
PMCPMC8285305
OpenAlexW3123285122

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.