ReviewHead and neck pathology2021
Oral Manifestations of Syphilis: a Review of the Clinical and Histopathologic Characteristics of a Reemerging Entity with Report of 19 New Cases.
Review in Head and neck pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oral Manifestations of Systemic Lupus Erythematosus: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Oral Manifestations of Secondary Syphilis.Cureus · 2026Article
- Multidisciplinary management of severe odontogenic maxillofacial multi-space infection in a patient with HIV-syphilis coinfection and advanced immunosuppression: a case report.Frontiers in cellular and infection microbiology · 2026Article
- A Case Report of Oral Syphilis Before and After Management.Clinical case reports · 2025Article
- Oropharyngeal Condyloma Lata in Secondary Syphilis: Case Report and Literature Review.The American journal of case reports · 2025Review
- Article
- Diagnostic Challenges of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the Hard Palate.Diagnostics (Basel, Switzerland) · 2025Review
- Oral manifestations of syphilis: A report of six cases.Journal of clinical and experimental dentistry · 2025Article
- Common white lesions of the oral cavity: Review of clinical presentations and management.Canadian family physician Medecin de famille canadien · 2025Review
- Innovative Combination of Tetracycline Rinse and CO₂ Laser Ablation for Treating White Sponge Nevus in Adolescents: A Case Study.The American journal of case reports · 2024Article
- Primary Syphilitic Glossitis.Head and neck pathology · 2024Article
- Not Always a Malignant Tumour: A Quiz.Acta dermato-venereologica · 2024Article
- Clinicopathologic assessment of secondary syphilis avoids misdiagnosis: results of comprehensive evaluation of 114 cases.Postepy dermatologii i alergologii · 2024Article
- Syphilitic Stomatitis: Raising Awareness on an Often-Overlooked Presentation of Secondary Syphilis.European journal of case reports in internal medicine · 2024Article
- Secondary oral syphilis presenting as a tumor-like lesion on the lower lip.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Oral Secondary Syphilis in an HIV-Positive Transgender Patient: A Case Report and Review of the Literature.Dentistry journal · 2023Article
- Ulceration and a White Lesion of the Tongue in a Male HIV Positive Patient: A Journey on the Avenue of Differential Diagnoses in Search of a Solution.Life (Basel, Switzerland) · 2023Article
- Extragenital Chancre in Men Who Have Sex with Men: Six Cases from China.Archives of sexual behavior · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSyphilis is a sexually-transmitted infectious disease caused by Treponema pallidum. Cases of primary and secondary syphilis are on the rise in the United States, with a 14.4% increase in new cases noted from 2017 to 2018 and an escalation of 71% between the years 2014 and 2018. Fulfilling its nickname of "the great imitator," oral manifestations of syphilis may mimic a variety of infectious, neoplastic, or immune-mediated processes, both clinically and histopathologically. This large spectrum of appearances can create a diagnostic challenge to the clinician and/or pathologist, leading to delay in diagnosis or misdiagnosis.
methodsA database of oral syphilis cases was created from archives at the University of Kentucky, University of Pittsburgh, LIJMC, Columbia University MC, and University of Tennessee. The age, sex, race, location, duration, and clinical description were recorded. Cases without positive reaction upon immunohistochemistry or serologic tests were excluded.
resultsWe identified 19 new cases of oral syphilis (17 males, one female, and one case unknown sex) and described the clinical and histopathological features of this re-emerging and potentially fatal disease. All cases demonstrated dense lymphoplasmacytic inflammation, often with inflammatory exocytosis or ulceration at the surface, and perivascular inflammation.
conclusionsEarly recognition of the histopathologic and clinical manifestations of oral syphilis is imperative for prompt diagnosis, improved patient outcomes, and disease prevention.
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