Evidence map›Paper›PMID 33459956›Full record

SynthesisInternational urology and nephrology2021

Nutritional status improvement in elderly CKD patients: a systematic review.

Adelina Mihaescu, Emmad Masood, Mohammed Zafran, Hassan Tahir Khokhar, Arlyn Maria Augustine, Aucella Filippo, Wim Van Biesen, Ken Farrigton, Juan Jesus Carrero, Adrian Covic and 1 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adelina MihaescuV Babes" University of Medicine and Pharmacy, Timișoara, Romania.
Emmad MasoodFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.
Mohammed ZafranFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.
Hassan Tahir KhokharFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.
Arlyn Maria AugustineFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.
Aucella FilippoScientific Institute for Research and Health Care, "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Wim Van BiesenDepartment of Internal Medicine - Nephrology, Ghent University, Ghent, Belgium.
Ken FarrigtonEast and North Hertfordshire NHS Trust, Lister Hospital, Stevenage, England.
Juan Jesus CarreroDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Adrian CovicUniversity of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.
Ionut NistorFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania. ionut.nistor@umfiasi.ro.ORCID http://orcid.org/0000-0002-1641-8992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlmost all CKD patients have a poor nutritional status, while elderly CKD patients are specifically frail and malnourished. Our aim is to conduct a systematic review of the up to date primary studies that look at methods of improving nutritional status in CKD patients in the elderly demographic.

methodsA focussed and sensitive search strategy was applied to the PUBMED database to identify relevant English language articles. Once articles were identified a detailed quality and bias assessment was performed. Two independent researchers (MZ and SM) then subsequently carried out detailed data extraction and analysis and this was subsequently verified by a third researcher (IN).

resultsA total of 19 studies were included in our systematic review which included 7 non-randomised control trials and 15 randomised controlled trials. The outcomes that we considered to be most relevant for our subject title were: mortality data, SGA, albumin, total protein, isoleucine, leucine, prealbumin, transferrin, leptin, valine, TAG, HDL, LDL and total amino acids. Detailed bias analysis of the different studies was also conducted.

conclusionThis is the first systematic review of the literature, so far, on the subject, involving elderly CKD patients. The quality of trials is low, very heterogenic in patients, methods and outcomes. However, we found a positive effect of dietary interventions on the nutritional status of most patients studied, highlighted by improvement in serum albumin and SGA, the most measured outcomes.

Indexed as

Nutritional StatusHumansMalnutritionRenal Insufficiency, ChronicChronic kidney diseaseElderly patientsFrailtyMalnutritionNutritional statusSerum albuminSGA

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.