Evidence map›Paper›PMID 33459839›Full record

ReviewClinical research in cardiology : official journal of the German Cardiac Society2021

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK).

A Yilmaz, J Bauersachs, F Bengel, R Büchel, I Kindermann, K Klingel, F Knebel, B Meder, C Morbach, E Nagel and 3 more

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Article
  7. Unraveling cardiac amyloidosis in Egypt: diagnostic challenges and disease outcomes.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Article
  8. Cardiac Amyloidosis: Pathogenesis, Diagnosis, and Treatment.Deutsches Arzteblatt international · 2026
    Review
  9. Semi-quantitative evaluation of early phaseAnnals of nuclear medicine · 2026
    Article
  10. Article
  11. CMR-based assessment of long-term effects of tafamidis in patients with cardiac transthyretin amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Observational
  12. QTc interval prolongation as a marker of disease stage in transthyretin cardiac amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  13. Review
  14. Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs.World journal of experimental medicine · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 2 countries.

A YilmazSektion für Herzbildgebung, Klinik für Kardiologie, Universitätsklinikum Münster, Von-Esmarch-Str. 48, 48149, Münster, Germany. ali.yilmaz@ukmuenster.de.ORCID http://orcid.org/0000-0003-4526-8679
J BauersachsKlinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany.
F BengelKlinik für Nuklearmedizin, Medizinische Hochschule Hannover, Hannover, Germany.
R BüchelKlinik für Nuklearmedizin, Universitätsspital Zürich, Zurich, Switzerland.
I KindermannKlinik für Innere Medizin III (Kardiologie, Angiologie und Internistische Intensivmedizin), Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg, Germany.
K KlingelInstitut für Pathologie und Neuropathologie, Universität Tübingen, Tübingen, Germany.
F KnebelMedizinische Klinik m.S. Kardiologie und Angiologie, Charite Universitätsmedizin Berlin Campus Mitte, Berlin, Germany.
B MederKlinik für Innere Medizin III, Universitätsklinikum Heidelberg, Heidelberg, Germany.
C MorbachKlinik für Innere Medizin III, Universitätsklinikum Heidelberg, Heidelberg, Germany.
E NagelInterdisziplinäres Amyloidosezentrum Nordbayern, Deutsches Zentrum für Herzinsuffizienz, Medizinische Klinik I der Universität Würzburg, Würzburg, Germany.
E Schulze-BahrInstitut für Experimentelle und translationale kardiovaskuläre Bildgebung, Universitätsklinikum Frankfurt, Frankfurt, Germany.
F Aus dem SiepenInstitut für Genetik von Herzerkrankungen (IfGH), Universitätsklinikum Münster, Münster, Germany.
N FreyKlinik für Innere Medizin III, Schwerpunkt Kardiologie und Angiologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
Heidelberg University · DEMedizinische Hochschule Hannover · DEUniversity Hospital Münster · DECharité - Universitätsmedizin Berlin · DEDeutsches Herzzentrum der Charité · DEGoethe University Frankfurt · DEUniversitätsklinikum des Saarlandes · DEUniversity Hospital of Zurich · CHUniversity Hospital Schleswig-Holstein · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation. For diagnostics, specific serum biomarkers and modern non-invasive imaging techniques, such as cardiovascular magnetic resonance imaging (CMR) and scintigraphic methods, are available today. These imaging techniques do not only complement conventional echocardiography, but also allow for accurate assessment of the extent of cardiac involvement, in addition to diagnosing cardiac amyloidosis. Endomyocardial biopsy still plays a major role in the histopathological diagnosis and subtyping of cardiac amyloidosis. The main objective of the diagnostic algorithm outlined in this position statement is to detect cardiac amyloidosis as reliably and early as possible, to accurately determine its extent, and to reliably identify the underlying subtype of amyloidosis, thereby enabling subsequent targeted treatment.

Indexed as

CardiologyDisease ManagementSocieties, MedicalAmyloidosisCardiomyopathiesDiagnosis, DifferentialDiagnostic ImagingElectrocardiographyGermanyHumansRadionuclide ImagingAmyloidosisEndomyocardial biopsyMagnetic resonance imagingMyocardiumScintigraphy

Identifiers

PMID33459839
PMCPMC8055575
OpenAlexW3121867295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.