ArticleThe Angle orthodontist2021
Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement.
Article in The Angle orthodontist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assesment of Two Different Modalities of Maxillary Canine Retraction Assisted With Injectable Platelet Rich Fibrin: A Prospective Clinical Study
Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin: A Prospective Clinical Study
The Effect of Multiple Injections of Platelets Rich Fibrin (i-PRF) on The Rate of Canine Retraction A Split-mouth: A Randomized Controlled Trial
The Effect of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Canine Retraction: A Randomized Controlled Clinical Trial
Assessment of the Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Root Resorption: A Randomized Controlled Clinical Trial
Evaluating the Effect of Injectable Platelet Rich Fibrin on Tooth Movement
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Effectiveness of different autologous platelet concentrates for orthodontic canine retraction following premolar extraction: a systematic review and meta-analysis.Progress in orthodontics · 2026Pooled it
- Pooled it
- The adjunctive effect of autologous platelet concentrates on orthodontic tooth movement: A systematic review and meta-analysis of current randomized controlled trials.International orthodontics · 2022Pooled it
- Effect of injectable platelet-rich fibrin on orthodontically induced root resorption during tooth movement: a biomarker-based randomized controlled trial.Clinical oral investigations · 2026Trial
- Effect of injectable platelet-rich fibrin on orthodontically induced apical root resorption following non-extraction-based orthodontic treatment in adults: A randomized controlled clinical trial.The Journal of international medical research · 2026Trial
- A three-arm parallel split-mouth randomized controlled trial comparing injectable platelet-rich fibrin and low-level laser therapy on the rate of orthodontic tooth movement and canine angulation during en-masse retraction.The Angle orthodontist · 2026Trial
- Does administration of injectable platelet-rich fibrin impact the overall treatment duration in orthodontic extraction cases? A randomized controlled trial.The Angle orthodontist · 2026Trial
- Effect of low-intensity pulsed ultrasound on the duration of mandibular anterior crowding correction and pain perception in adults undergoing orthodontic treatment: a single-blinded randomized control trial.Dental press journal of orthodontics · 2025Trial
- Trial
- Does leukocyte-platelet-rich fibrin (L-PRF) cause long term acceleration in the rate of canine retraction? A split-mouth, two-arm parallel group, randomized control trial.Dental press journal of orthodontics · 2023Trial
- Role of Mesenchymal Stem Cell Exosomes and Injectable Platelet Rich Fibrin on Structure and Function of Submandibular Salivary Gland of Aged Albino Rats.The Saudi dental journal · 2025Article
- Injectable platelet rich fibrin versus low-level laser therapy for orthodontic tooth movement: A clinical split-mouth study.Bioinformation · 2025Article
- Effectiveness of autologous leukocyte-platelet-rich fibrin on the rate of maxillary canine retraction, rotation, pain, and soft tissue healing: A split-mouth randomized controlled trial.Korean journal of orthodontics · 2024Article
- Integrated bioinformatic analysis of protein landscape in gingival crevicular fluid unveils sequential bioprocess in orthodontic tooth movement.Progress in orthodontics · 2024Review
- Gingival Augmentation Using Injectable Platelet-Rich Fibrin (i-PRF)-A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- Review
- The age-related effects on orthodontic tooth movement and the surrounding periodontal environment.Frontiers in physiology · 2024Review
- Novel approaches to the use of platelet-rich fibrin: A literature review.The Saudi dental journal · 2023Review
- Do platelet concentrates accelerate orthodontic tooth movement?: a systematic review.Journal of periodontal & implant science · 2023Article
- Effect of local injection of injectable platelet-rich fibrin on bone remodeling during orthodontic tooth movement in dogs.Dental research journal · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the efficiency of injectable platelet-rich fibrin (i-PRF) in accelerating canine tooth movement and to examine levels of the matrix metalloproteinase-8 (MMP-8), interleukin-1β (IL-1β), receptor activator of nuclear factor kappa-light-chain-enhancer of activated B cells ligand (RANKL), and osteoprotegerin (OPG) in the gingival crevicular fluid during orthodontic treatment. MATERIALS AND
methodsTwenty patients (mean age = 21.4 ± 2.9 years) with Class II Division 1 malocclusion were included in a split-mouth study. The treatment plan for all patients was extraction of maxillary first premolars followed by canine distalization with closed-coil springs using 150 g of force on each side. The study group received i-PRF two times, with a 2-week interval, on one side of the maxilla. The contralateral side served as the control and did not receive i-PRF. Maxillary canine tooth movement was measured at five time points (T1-T5) on each side. Also, the activity of inflammatory cytokines was evaluated at three time points in the gingival crevicular fluid samples.
resultsThere was a significant difference in canine tooth movement between the two groups (P < .001). i-PRF significantly increased the rate of tooth movement, and stimulation in the levels of inflammatory cytokines supported this result (P < .001). The levels of cytokines changed in both groups between T1 and T2. The IL-1β, MMP8, and RANKL values were significantly increased in the study group compared with the control group, while the OPG values were significantly decreased.
conclusionsi-PRF-facilitated orthodontics is an effective and safe treatment modality to accelerate tooth movement, and this method can help shorten orthodontic treatment duration.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.