Evidence map›Paper›PMID 33459664›Full record

ArticleJournal of Parkinson's disease2021

People with Parkinson's Disease: What Symptoms Do They Most Want to Improve and How Does This Change with Disease Duration?

Rebecca J Port, Martin Rumsby, Graham Brown, Ian F Harrison, Anneesa Amjad, Claire J Bale

3 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05733819 phase1completednot on this mapstarted 2023, after this paper: background citation

Responders to Metronome-based Rhythmic Auditory Cueing in Parkinson Disease

TypeinterventionalSponsorBoston University Charles River CampusRan2023 to 2023Enrolled31ConditionsParkinson DiseaseArmsSubject-specific optimized RAS, Active Walking
NCT06324422 narecruitingnot on this mapstarted 2024, after this paper: background citation

Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?

TypeinterventionalSponsorUniversity of AarhusRan2024 to 2026Enrolled94ConditionsParkinson's DiseaseArmsAerobic exercise intervention, Resistance exercise intervention
NCT06707402 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of 24 Weeks Community-based Brisk Walking on Physical Function, Comorbidities, Cognition, Disease Severity, and Health-related Quality of Life in People With Parkinson's Disease.

TypeinterventionalSponsorUniversity of AarhusRan2025 to 2027Enrolled129ConditionsParkinson DiseaseArmsWALK, ACTIVE, CON
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. What medicines do people with Parkinson's disease want?Journal of Parkinson's disease · 2026
    Review
  9. Article
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  11. Article
  12. Observational
  13. Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rebecca J PortParkinson's UK, London, UK.
Martin RumsbyResearch Support Network, London, UK.
Graham BrownResearch Support Network, London, UK.
Ian F HarrisonCentre for Advanced Biomedical Imaging, Department of Imaging, Division of Medicine, University College London, London, UK.
Anneesa AmjadParkinson's UK, London, UK.
Claire J BaleParkinson's UK, London, UK.
Parkinson's UK · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is a neurodegenerative condition with a diverse and complex pattern of motor and non-motor symptoms which change over time with disease duration.

objectiveThe aims of the present study were to discover what symptoms matter most to people with the condition and to examine how these priorities change with disease duration.

methodsA simple free-text online survey (using SmartSurvey) was developed by Parkinson's UK, which asked participants to identify up to three aspects of the condition they would most like to see improvement in.

results790 people participated reporting 2,295 issues related to PD which were grouped into 24 broad symptom domains. Of these, 1,358 (59.1%) were categorised as motor symptoms, 859 (37.4%) as non-motor issues and 78 (3.4%) as medication problems. This study reveals how certain features of PD become more or less important to patients as the condition progresses. Non-motor symptoms were highly cited from the very earliest stages of PD. Problems with walking, balance and falls, speech problems, freezing and dyskinesia become increasingly important as the condition progresses whereas tremor, stiffness and psychological health become decreasingly important as the condition progresses.

conclusionsThe data suggest that the priorities of people affected by PD for improving life are personal and change with duration of the condition. These findings have implications for developing person-centred management and care, as well as for directing future research to improve quality of life.

Indexed as

DyskinesiasParkinson DiseaseHumansQuality of LifeSurveys and QuestionnairesTremorParkinson’s diseasepatient prioritiesprogressionquality of lifesymptoms

Identifiers

PMID33459664
PMCPMC8150663
OpenAlexW3120345228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.