ArticleJournal of Alzheimer's disease : JAD2021
Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Machine learning and data-driven inverse modeling of metabolomics unveil key processes of active aging.NPJ systems biology and applications · 2025Trial
- A polygenetic rat model of divergent aerobic capacity reveals a liver-brain interaction impacting Alzheimer's disease-like phenotypes.The Journal of physiology · 2026Article
- Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer's disease.Brain : a journal of neurology · 2026Article
- Male Rat Model of Chemical Androgen Deprivation and Estrogenization from the Perspective of Anthropometric, Histological, and Biochemical Parameters.Medicina (Kaunas, Lithuania) · 2025Article
- Predictive value of biliverdin reductase-A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes.Journal of diabetes investigation · 2025Article
- Biomarker and cognitive decline in atrial fibrillation: a prospective cohort study.Scientific reports · 2025Article
- Association of high serum aspartate transaminase to high density lipoprotein-cholesterol ratio with probable dementia among people living with HIV on antiretroviral therapy in Southwestern Uganda.SAGE open medicine · 2025Article
- Five-year dementia prediction and decision support system based on real-world data.Frontiers in aging neuroscience · 2025Article
- Association Between Diabetes and Site-Specific Cancer Risk: A Population-Based Cohort Study on the Differential Role of Metabolic Profiles.Journal of diabetes research · 2025Article
- Liver enzyme and risk of vascular dementia: A univariable and multivariable Mendelian randomization of European descent.Neuroprotection (Chichester, England) · 2024Article
- Cognitive impairment in patients awaiting kidney and liver transplantation-A clinically relevant problem?Brain and behavior · 2024Article
- Article
- Liver integrity and the risk of Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Associations of Serum Liver Function with Cerebral Blood Flow in Patients with Alzheimer's Disease.Journal of Alzheimer's disease reports · 2024Article
- Association of liver function markers and apolipoprotein E ε4 with pathogenesis and cognitive decline in Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Non-linear association of liver enzymes with cognitive performance in the elderly: A cross-sectional study.PloS one · 2024Article
- Reduced liver damage and fibrosis with combined SCD Probiotics and intermittent fasting in aged rat.Journal of cellular and molecular medicine · 2024Article
- U-shaped link of health checkup data and need for care using a time-dependent cox regression model with a restricted cubic spline.Scientific reports · 2023Article
- Association of Serum Liver Enzymes with Brain Amyloidopathy and Cognitive Performance.Journal of Alzheimer's disease reports · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundLow levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the low physiologic range, surrogate markers for reduced liver metabolic function, are associated with cerebral hypometabolism, impairment in neurotransmitter production and synaptic maintenance, and a higher prevalence of dementia. It is unknown whether a prospective association exists between low liver enzyme levels and incident dementia.
objectiveTo determine whether low levels of ALT and AST are associated with higher risk of incident dementia.
methodsPlasma ALT and AST were measured on 10,100 study participants (mean age 63.2 years, 55% female, 22% black) in 1996-1998. Dementia was ascertained from comprehensive neuropsychological assessments, annual contact, and medical record surveillance. Cox proportional hazards regression was used to estimate the association.
resultsDuring a median follow-up of 18.3 years (maximum 21.9 years), 1,857 individuals developed dementia. Adjusted for demographic factors, incidence rates of dementia were higher at the lower levels of ALT and AST. Compared to the second quintile, ALT values <10th percentile were associated with a higher risk of dementia (hazard ratio [HR] 1.34, 95% CI 1.08-1.65). The corresponding HR was 1.22 (0.99-1.51) for AST.
conclusionPlasma aminotransferases <10th percentile of the physiologic range at mid-life, particularly ALT, were associated with greater long-term risk of dementia, advocating for attention to the putative role of hepatic function in the pathogenesis of dementia.
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