Evidence map›Paper›PMID 33459124›Full record

ArticleRenal failure2021

Pro-inflammatory cytokines as potential predictors for intradialytic hypotension.

Jinbo Yu, Xiaohong Chen, Yang Li, Yaqiong Wang, Xuesen Cao, Zhonghua Liu, Bo Shen, Jianzhou Zou, Xiaoqiang Ding

Open access · goldAbstract read
In one paragraph

Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  12. Involvement of Inflammasome Components in Kidney Disease.Antioxidants (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jinbo YuDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Xiaohong ChenDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Yang LiDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Yaqiong WangDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Xuesen CaoDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Zhonghua LiuDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Bo ShenDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Jianzhou ZouDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Xiaoqiang DingDivision of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, PR China.
Shanghai Institute of Hematology · CNShanghai Medical College of Fudan University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntradialytic hypotension (IDH) is a common complication in maintaining hemodialysis (MHD) patients. Immune activation might be part of the mechanisms. However, the association between pro-inflammatory cytokines and blood pressure (BP) has not been deeply explored. So we aim to evaluate the potential role of pro-inflammatory cytokines in IDH.

methodsMHD patients starting hemodialysis before January 2016 were enrolled in our retrospective study. Patients' characteristics, laboratory results, and intradialytic BP were collected. IDH was defined as nadir systolic BP ≤ 90 mmHg during hemodialysis. The definition of IDH group was that those who suffered from more than one hypotensive event during one month after the enrollment (10% of dialysis treatments). Spearman correlation analysis and logistic regression were employed to explore the relationship between pro-inflammatory cytokines and IDH.

resultsAmong 390 patients, 72 were identified with IDH (18.5%). High levels of serum tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were observed in the IDH group (

conclusionPro-inflammatory cytokines (TNF-α and IL-1β) could be potential predictors for IDH.

Indexed as

AgedBlood PressureFemaleHumansHypotensionInterleukin-1betaKidney Failure, ChronicLogistic ModelsMaleMiddle AgedRenal DialysisRetrospective StudiesRisk FactorsROC CurveTumor Necrosis Factor-alphaInterleukin-1betaTumor Necrosis Factor-alphahemodialysisinterleukin-1βIntradialytic hypotensionpro-inflammatory cytokinestumor necrosis factor-α

Identifiers

PMID33459124
PMCPMC7833080
OpenAlexW3125395332

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.