Evidence map›Paper›PMID 33459116›Full record

ReviewCell cycle (Georgetown, Tex.)2021

Role of Aurora B and Haspin kinases in the metaphase Topoisomerase II checkpoint.

M Johansson, Y Azuma, D J Clarke

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Histone H3 tail modifications required for meiosis inbioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

M JohanssonDepartment of Genetics, Cell Biology & Development, University of Minnesota , Minneapolis, MN, USA.
Y AzumaDepartment of Molecular Biosciences, University of Kansas , Lawrence, KS, USA.ORCID 0000-0002-9634-6676
D J ClarkeDepartment of Genetics, Cell Biology & Development, University of Minnesota , Minneapolis, MN, USA.
University of Minnesota · USUniversity of Kansas · US

Funding

Control of Chromosome Segregation by DNA Topoisomerase IIR01GM130858 · NIGMS · UNIVERSITY OF MINNESOTA · PI DUNCAN J. CLARKE · 2019 to 2026
$2.2M
Regulation of kinetochore function by Topoisomerase IIR01GM112793 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI AZUMA, YOSHIAKI, CLARKE, DUNCAN J. · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM112793NIGMS NIH HHS R01 GM130858
6 · The paper itself

Abstract

DNA Topoisomerase II (TopoII) uses ATP hydrolysis to decatenate chromosomes so that sister chromatids can faithfully segregate in mitosis. When the TopoII enzyme cycle stalls due to failed ATP hydrolysis, the onset of anaphase is delayed, presumably to allow extra time for decatenation to be completed. Recent evidence revealed that, unlike the spindle assembly checkpoint, this TopoII checkpoint response requires Aurora B and Haspin kinases and is triggered by SUMOylation of the C-terminal domain of TopoII.

Indexed as

AnimalsAurora Kinase BCell Cycle ProteinsDNA Topoisomerases, Type IIGenes, cdcHumansIntracellular Signaling Peptides and ProteinsMetaphaseMitosisM Phase Cell Cycle CheckpointsProtein Serine-Threonine KinasesAURKB protein, humanAurora Kinase BCell Cycle ProteinsDNA Topoisomerases, Type IIHASPIN protein, humanIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesAurora BcheckpointHaspinmitosisTopoisomerase II

Identifiers

PMID33459116
PMCPMC7894448
OpenAlexW3122015478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.