Evidence map›Paper›PMID 33458897›Full record

ArticleChembiochem : a European journal of chemical biology2021

High-Resolution DNA Dual-Rulers Reveal a New Intermediate State in Ribosomal Frameshifting.

Yujia Mao, Ran Lin, Shoujun Xu, Yuhong Wang

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yujia MaoDepartment of Chemistry, University of Houston, 3585 Cullen Blvd, Houston, TX 77204, USA.
Ran LinDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Shoujun XuDepartment of Chemistry, University of Houston, 3585 Cullen Blvd, Houston, TX 77204, USA.ORCID 0000-0002-8719-2951
Yuhong WangDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Funding

EF-Tu mutagenesis and functional studyR01GM111452 · NIGMS · UNIVERSITY OF HOUSTON · PI YUHONG WANG, Shoujun Xu · 2015 to 2026
$3.2M
NIGMS NIH HHS R01 GM111452Welch Foundation E-1721
6 · The paper itself

Abstract

Ribosomal frameshifting is an important pathway used by many viruses for protein synthesis that involves mRNA translocation of various numbers of nucleotides. Resolving the mRNA positions with subnucleotide precision will provide critical mechanistic information that is difficult to obtain with current techniques. We report a method of high-resolution DNA rulers with subnucleotide precision and the discovery of new frameshifting intermediate states on mRNA containing a GA

Indexed as

Base SequenceFrameshifting, RibosomalFusidic AcidProtein BiosynthesisReading FramesRibosomesRNA, MessengerFusidic AcidRNA, Messengerantibioticsatomic magnetometerDNA rulersforce spectroscopyribosomal frameshift

Identifiers

PMID33458897
PMCPMC8014572

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.