ArticleThe New phytologist2021
A (conditional) role for labdane-related diterpenoid natural products in rice stomatal closure.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Divergent roles of ent-kaurene oxidase paralogs in rice momilactone biosynthesis.Journal of integrative plant biology · 2026Article
- Rice resistance to lepidopteran herbivores is enhanced by overexpression of a key transcription factor gene for diterpenoid phytoalexin biosynthesis.Plant biotechnology (Tokyo, Japan) · 2026Article
- An Ustilaginoidea virens Nuclear Effector SCRE7 Inhibits Rice Immunity via Suppressing OsLBD11/12-Promoted Transcription of OsCPS2.Plant biotechnology journal · 2026Article
- The role of isoprenoids in the chemical interaction between plants and other organisms in their rhizosphere.aBIOTECH · 2025Review
- Identification of a novel screening strategy of rice resistance breeding through phytoalexin content.Planta · 2025Article
- Evolutionary Systems Biology Identifies Genetic Trade-offs in Rice Defense against Aboveground and Belowground Attackers.Plant & cell physiology · 2025Article
- Diterpenoid Phytoalexins Shape Rice Root Microbiomes and Their Associations With Root Parasitic Nematodes.Environmental microbiology · 2025Article
- Meta-analysis of public RNA-sequencing data of drought and salt stresses in different phenotypes of resistant and susceptibleQuantitative plant biology · 2025Article
- Enhancing Crop Resilience: Insights from Labdane-Related Diterpenoid Phytoalexin Research in Rice (Current issues in molecular biology · 2024Review
- Double-barreled defense: dualaBIOTECH · 2024Article
- Biochemical analysis of the TPS-a subfamily inFrontiers in plant science · 2024Article
- BSR1, a Rice Receptor-like Cytoplasmic Kinase, Positively Regulates Defense Responses to Herbivory.International journal of molecular sciences · 2023Article
- A dolabralexin-deficient mutant provides insight into specialized diterpenoid metabolism in maize.Plant physiology · 2023Article
- Article
- Plant (di)terpenoid evolution: from pigments to hormones and beyond.Natural product reports · 2023Review
- Rice Phytoalexins: Half a Century of Amazing Discoveries; Part I: Distribution, Biosynthesis, Chemical Synthesis, and Biological Activities.Plants (Basel, Switzerland) · 2023Review
- Plant biosynthetic gene clusters in the context of metabolic evolution.Natural product reports · 2022Review
- Deceptive Complexity in Formation of Cleistantha-8,12-diene.Organic letters · 2022Article
- Dissecting the labdane-related diterpenoid biosynthetic gene clusters in rice reveals directional cross-cluster phytotoxicity.The New phytologist · 2022Article
- Screening for Abiotic Stress Response in Rice.Methods in molecular biology (Clifton, N.J.) · 2022Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
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Abstract
Rice (Oryza sativa) is the staple food for over half the world's population. Drought stress imposes major constraints on rice yields. Intriguingly, labdane-related diterpenoid (LRD) phytoalexins in maize (Zea mays) affect drought tolerance, as indicated by the increased susceptibility of an insertion mutant of the class II diterpene cyclase ZmCPS2/An2 that initiates such biosynthesis. Rice also produces LRD phytoalexins, utilizing OsCPS2 and OsCPS4 to initiate a complex metabolic network. For genetic studies of rice LRD biosynthesis the fast-growing Kitaake cultivar was selected for targeted mutagenesis via CRISPR/Cas9, with an initial focus on OsCPS2 and OsCPS4. The resulting cps2 and cps4 knockout lines were further crossed to create a cps2x4 double mutant. Both CPSs also were overexpressed. Strikingly, all of the cv Kitaake cps mutants exhibit significantly increased susceptibility to drought, which was associated with reduced stomatal closure that was evident even under well-watered conditions. However, CPS overexpression did not increase drought resistance, and cps mutants in other cultivars did not alter susceptibility to drought, although these also exhibited lesser effects on LRD production. The results suggest that LRDs may act as a regulatory switch that triggers stomatal closure in rice, which might reflect the role of these openings in microbial entry.
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