Evidence map›Paper›PMID 33458688›Full record

ArticleCritical care explorations2021

Postcardiac Arrest Neuroprognostication Practices: A Survey of Brazilian Physicians.

Sonya E Zhou, Mary M Barden, Emily J Gilmore, Octavio M Pontes-Neto, Gisele Sampaio Silva, Pedro Kurtz, Jamary Oliveira-Filho, Pedro Telles Cougo-Pinto, Fernando G Zampieri, Nicholas J Napoli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Sonya E ZhouDepartment of Neurology, Yale University School of Medicine, New Haven, CT.
Mary M BardenDepartment of Neurology, Yale University School of Medicine, New Haven, CT.
Emily J GilmoreDepartment of Neurology, Yale University School of Medicine, New Haven, CT.
Octavio M Pontes-NetoStroke Service, Neurology Division, Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Gisele Sampaio SilvaDepartment of Neurology and Neurosurgery, Universidade Federal de São Paulo, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Pedro KurtzInstituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil.
Jamary Oliveira-FilhoPost-Graduate Program in Health Sciences, Federal University of Bahia, Bahia, Brazil.
Pedro Telles Cougo-PintoHospital Samaritano, Rio de Janeiro, Brazil.
Fernando G ZampieriResearch Institute, HCor, Hospital of Coração, São Paulo, Brazil.
Nicholas J NapoliDepartment of Electrical and Computer Engineering, University of Florida, Herbert Wertheim College of Engineering, Gainesville, FL.
Jeremy J TheriotDepartment of Neurology, University of Utah, Salt Lake City, UT.
David M GreerDepartment of Neurology, Yale University School of Medicine, New Haven, CT.
Carolina B MacielDepartment of Neurology, Yale University School of Medicine, New Haven, CT.
Yale University · USBoston University · USHospital Samaritano de São Paulo · BRInstituto Estadual do Cérebro Paulo Niemeyer · BRUniversidade de São Paulo · BRUniversity of Southern Denmark · DK

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Short-Term Reserch Training: Students in Health SchoolsT35HL007649 · NHLBI · YALE UNIVERSITY · PI Sarwat I Chaudhry, Erica L Herzog · 1987 to 2026
$5.7M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T35 HL007649
6 · The paper itself

Abstract

End-of-life care and decisions on withdrawal of life-sustaining therapies vary across countries, which may affect the feasibility of future multicenter cardiac arrest trials. In Brazil, withdrawal of life-sustaining therapy is reportedly uncommon, allowing the natural history of postcardiac arrest hypoxic-ischemic brain injury to present itself. We aimed to characterize approaches to neuroprognostication of cardiac arrest survivors among physicians in Brazil.

designCross-sectional study.

settingBetween August 2, 2019, and July 31, 2020, we distributed a web-based survey to physicians practicing in Brazil. SUBJECTS: Physicians practicing in Brazil and members of the Brazilian Association of Neurointensive Care, who care for patients resuscitated following cardiac arrest.

interventionsNot applicable. MEASUREMENTS AND MAIN

resultsResponses from 185 physicians were obtained. Pupillary reflexes, corneal reflexes, and motor responses were considered critical to prognostication, whereas neuroimaging and electroencephalography were also regarded as important. For patients without targeted temperature management, absent pupillary and corneal reflexes at 24 hours postarrest were considered strongly predictive of poor neurologic outcome by 31.8% and 33.0%, respectively. For targeted temperature management-treated patients, absent pupillary and corneal reflexes at 24-hour postrewarming were considered prognostic by 22.9% and 20.0%, respectively. Physicians felt comfortable making definitive prognostic recommendations at day 6 postarrest or later (34.2%) for nontargeted temperature management-treated patients, and at day 6 postrewarming (20.4%) for targeted temperature management-treated patients. Over 90% believed that improving neuroprognostic accuracy would affect end-of-life decision-making.

conclusionsThere is significant variability in neuroprognostic approaches to postcardiac arrest patients and timing of prognostic studies among Brazilian physicians, with practices frequently deviating from current guidelines, underscoring a need for greater neuroprognostic accuracy. Nearly all physicians believed that improving neuroprognostication will impact end-of-life decision-making. Given the tendency to delay prognostic recommendations while using similar neuroprognostic tools, Brazil offers a unique cohort in which to examine the natural history of hypoxic-ischemic brain injury in future studies.

Indexed as

cardiac arrestheart arrestneurologic examinationneuroprognosticationoutcomes assessmentpostcardiac arrest syndrome

Identifiers

PMID33458688
PMCPMC7803669
OpenAlexW3123905475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.