Evidence map›Paper›PMID 33458625›Full record

ArticleiScience2021

Chronic lymphocytic leukemia B-cell-derived TNFα impairs bone marrow myelopoiesis.

Bryce A Manso, Jordan E Krull, Kimberly A Gwin, Petra K Lothert, Baustin M Welch, Anne J Novak, Sameer A Parikh, Neil E Kay, Kay L Medina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bryce A MansoDepartment of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Jordan E KrullDepartment of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Kimberly A GwinDepartment of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Petra K LothertDepartment of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Baustin M WelchDepartment of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Anne J NovakDepartment of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Sameer A ParikhDivision of Hematology, Mayo Clinic, Rochester, MN 55905, USA.
Neil E KayDivision of Hematology, Mayo Clinic, Rochester, MN 55905, USA.
Kay L MedinaDepartment of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Mayo Clinic · USWinnMed · US

Funding

PHD TRAINING PROGRAM IN BASIC IMMUNOLOGYT32AI007425 · NIAID · MAYO CLINIC ROCHESTER · PI SHAPIRO, VIRGINIA SMITH · 1995 to 2020
$3.6M
NIAID NIH HHS T32 AI007425
6 · The paper itself

Abstract

TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture of CLL B cells with purified normal human hematopoietic stem and progenitor cells (HSPCs) directly altered protein levels of the myeloid and erythroid cell fate determinants PU.1 and GATA-2 at the single-cell level within transitional HSPC subsets, mimicking

Indexed as

ImmunologyMolecular BiologyStem Cells Research

Identifiers

PMID33458625
PMCPMC7797930
OpenAlexW3115955501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.