ArticlePhysics and imaging in radiation oncology2018
The effect of density overrides on magnetic resonance-guided radiation therapy planning for lung cancer.
Article in Physics and imaging in radiation oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Stereotactic body radiotherapy of central lung tumours using a 1.5 T MR-linac: First clinical experiences.Clinical and translational radiation oncology · 2024Article
- Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer.Frontiers in oncology · 2021Article
- Imaging science and development in modern high-precision radiotherapy.Physics and imaging in radiation oncology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeInverse treatment planning for lung cancer can be challenging since density heterogeneities may appear inside the planning target volume (PTV). One method to improve the quality of intensity modulation is the override of low density tissues inside the PTV during plan optimization. For magnetic resonance-guided radiation therapy (MRgRT), where the influence of the magnetic field on secondary electrons is sensitive to the tissue density, the reliability of density overrides has not yet been proven. This work, therefore, gains a first insight into density override strategies for MRgRT. MATERIAL AND
methodsMonte Carlo-based treatment plans for five lung cancer patients were generated based on free-breathing CTs and two density override strategies. Different magnetic field configurations were considered with their effect being accounted for during optimization. Optimized plans were forward calculated to 4D-CTs and accumulated for the comparison of planned and expected delivered dose.
resultsFor MRgRT, density overrides led to a discrepancy between the delivered and planned dose. The tumor volume coverage deteriorated for perpendicular magnetic fields of 1.5 T to 93.6% (D
conclusionsIn this work, first results on the effect of density overrides on treatment planning for MRgRT are presented. It was observed that the underestimation of magnetic field effects in overridden densities during treatment planning resulted in an altered delivered dose, depending on the field strength and orientation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.