ArticlePhysics and imaging in radiation oncology2018
An uncertainty metric to evaluate deformation vector fields for dose accumulation in radiotherapy.
Article in Physics and imaging in radiation oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Robust organ mapped dose: using multiple image registrations to identify deformation uncertainty in radiation dose mapping.Physics in medicine and biology · 2026Article
- Comparative evaluation of dose accumulation strategies in the clinical reirradiation setting.Physics and imaging in radiation oncology · 2026Article
- Review and recommendations on deformable image registration uncertainties for radiotherapy applications.Physics in medicine and biology · 2023Review
- Accuracy of patient setup positioning using surface-guided radiotherapy with deformable registration in cases of surface deformation.Journal of applied clinical medical physics · 2022Article
- Adaptive Radiation Therapy (ART) Strategies and Technical Considerations: A State of the ART Review From NRG Oncology.International journal of radiation oncology, biology, physics · 2021Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIn adaptive radiotherapy, deformable image registration (DIR) is used to propagate delineations of tumors and organs into a new therapy plan and to calculate the accumulated total dose. Many DIR accuracy metrics have been proposed. An alternative proposed here could be a local uncertainty (LU) metric for DIR results. MATERIALS AND
methodsThe LU represented the uncertainty of each DIR position and was focused on deformation evaluation in uniformly-dense regions. Four cases demonstrated LU calculations: two head and neck cancer cases, a lung cancer case, and a prostate cancer case. Each underwent two CT examinations for radiotherapy planning.
resultsLU maps were calculated from each DIR of the clinical cases. Reduced fat regions had LUs of 4.6 ± 0.9 mm, 4.8 ± 1.0 mm, and 4.5 ± 0.7 mm, while the shrunken left parotid gland had a LU of 4.1 ± 0.8 mm and the shrunken lung tumor had a LU of 3.7 ± 0.7 mm. The bowels in the pelvic region had a LU of 10.2 ± 3.7 mm. LU histograms for the cases were similar and 99% of the voxels had a LU < 3 mm.
conclusionsLU is a new uncertainty metric for DIR that was demonstrated for clinical cases. It had a tolerance of <3 mm.
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