Evidence map›Paper›PMID 33457411›Full record

ArticleBioMed research international2020

miR-1929-3p Overexpression Alleviates Murine Cytomegalovirus-Induced Hypertensive Myocardial Remodeling by Suppressing Ednra/NLRP3 Inflammasome Activation.

YongJia Wang, Zhen Huang, Hua Zhong, LaMei Wang, DongMei Xi, YunZhong Shi, Wei Zhou, YongMin Liu, Na Tang, Fang He

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. MicroRNAs in cardiovascular diseases.Medical review (2021) · 2022
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

YongJia Wang *Department of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0001-9454-1008
Zhen Huang *Department of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0002-0737-9725
Hua Zhong *Department of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0002-7049-4590
LaMei WangCentre of Medical Functional Experiments, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0003-4854-6195
DongMei XiDepartment of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0002-1009-363X
YunZhong ShiDepartment of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0001-7853-3593
Wei ZhouDepartment of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0002-3471-5288
YongMin LiuDepartment of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0002-1180-902X
Na TangDepartment of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0001-6304-253X
Fang HeDepartment of Pathophysiology, Key Laboratory of Education, Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi 832002, China.ORCID https://orcid.org/0000-0001-6912-6187
Shihezi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) play crucial roles in the development of essential hypertension (EH). Previously, we found that the expression of miR-1929-3p was decreased in C57BL/6 mice with hypertension induced by murine cytomegalovirus (MCMV). In this study, we explored the role of miR-1929-3p in hypertension myocardial remodeling in MCMV-infected mice. First, we measured MCMV DNA and host IgG and IgM after infection and determined the expression of miR-1929-3p and its target gene endothelin A receptor (Ednra) mRNA in the myocardium of mice. Then, we performed invasive blood pressure (BP) monitoring. Heart-to-body weight ratio (HW/BW%), along with mRNA levels of B-type natriuretic peptide (BNP) and beta myosin heavy chain (

Indexed as

MuromegalovirusAnimalsBlood PressureCytokinesEndothelin-1Enzyme-Linked Immunosorbent AssayHerpesviridae InfectionsHypertensionImmunoglobulin GImmunoglobulin MInflammasomesInflammationInterleukin-18Interleukin-1betaMiceMice, Inbred C57BLCytokinesEndothelin-1Immunoglobulin GImmunoglobulin MInflammasomesInterleukin-18Interleukin-1betaMicroRNAsMIRN1929 microRNA, mouseNatriuretic Peptide, BrainNLR Family, Pyrin Domain-Containing 3 ProteinReceptor, Endothelin AVentricular Myosins

Identifiers

PMID33457411
PMCPMC7787724
OpenAlexW3117507846

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.